Evidence map›Paper›PMID 33798640›Full record

ArticleJournal of dentistry2021

Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics-A preliminary assessment.

Jie Liu, Chao-An Chen, Xiaofei Zhu, Brian R Morrow, Ukrit Thamma, Tia J Kowal, Hassan M Moawad, Matthias M Falk, Himanshu Jain, George T-J Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Jie LiuDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 38163, United States. Electronic address: liu.7050@osu.edu.
Chao-An ChenDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 38163, United States; Department of Endodontics, Chi Mei Medical Center, Liouying, Tainan, Taiwan; Department of Endodontics, Chi Mei Medical Center, Yongkang, Tainan, Taiwan. Electronic address: hardstone49@gmail.com.
Xiaofei ZhuDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 38163, United States; VIP Dental Service and Geriatric Dentistry, School and Hospital of Stomatology, Peking University, Beijing, China. Electronic address: zhuxiaofei767@foxmail.com.
Brian R MorrowDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 38163, United States. Electronic address: morrow@uthsc.edu.
Ukrit ThammaDepartment of Materials Science and Engineering, Lehigh University, Bethlehem, PA, 18015, United States. Electronic address: ukritthamma@gmail.com.
Tia J KowalDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, 18015, United States. Electronic address: tjkowal317@gmail.com.
Hassan M MoawadDepartment of Materials Science and Engineering, Lehigh University, Bethlehem, PA, 18015, United States. Electronic address: hmm205@lehigh.edu.
Matthias M FalkDepartment of Biological Sciences, Lehigh University, Bethlehem, PA, 18015, United States. Electronic address: mmf4@lehigh.edu.
Himanshu JainDepartment of Materials Science and Engineering, Lehigh University, Bethlehem, PA, 18015, United States. Electronic address: h.jain@lehigh.edu.
George T-J HuangDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 38163, United States. Electronic address: gtjhuang@uthsc.edu.
Lehigh University · USUniversity of Tennessee Health Science Center · US

Funding

Stem Cell Based Therapy for Regenerative Endodontics R01DE019156 · NIDCR · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HUANG, GEORGE T.J · 2008 to 2013
$1.8M
NIDCR NIH HHS R01 DE019156
6 · The paper itself

Abstract

INTRODUCTION/

objectiveThe tailored amorphous multi-porous (TAMP) material fabrication technology has led to a new class of bioactive materials possessing versatile characteristics. It has not been tested for dental applications. Thus, we aimed to assess its biocompatibility and ability to regenerate dental mineral tissue.

methods30CaO-70SiO

resultsThe in vitro assays showed that DPSCs attached well onto the TAMP discs with comparable viability to those attached to culture plates. Pulp capping tests on mini-swine showed that after 4.5 months TAMP material was still present at the capping site, and mineral tissue (dentin bridge) had formed in all sizes of pulp exposure underneath the TAMP material.

conclusionsTAMP calcium silicate is biocompatible with both human and swine DPSCs in vitro and with pulp in vivo, it may help regenerate the dentin bridge after pulp exposure.

Indexed as

Dental Pulp CappingRegenerative EndodonticsAnimalsCalcium CompoundsDental PulpSilicatesSwineCalcium Compoundscalcium silicateSilicatesBioactive materialsCalcium silicateDental pulp stem cellsDentin-pulpRegenerative endodonticsTailored amorphous multiporous (TAMP)Tissue regeneration

Identifiers

PMID33798640
PMCPMC8206035
OpenAlexW3145151731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.