Evidence map›Paper›PMID 33798637›Full record

ArticleBrain, behavior, and immunity2021

Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility.

Michaela R Breach, Courtney N Dye, Aarohi Joshi, Steven Platko, Rachel A Gilfarb, Annemarie R Krug, Dominic V Franceschelli, Anabel Galan, Claire M Dodson, Kathryn M Lenz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  11. Mast Cells in Autism Spectrum Disorder-The Enigma to Be Solved?International journal of molecular sciences · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. The immune cell profile of the developing rat brain.Brain, behavior, and immunity · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michaela R BreachNeuroscience Graduate Program, The Ohio State University, Columbus, OH, USA.
Courtney N DyeNeuroscience Graduate Program, The Ohio State University, Columbus, OH, USA.
Aarohi JoshiDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Steven PlatkoDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Rachel A GilfarbNeuroscience Graduate Program, The Ohio State University, Columbus, OH, USA.
Annemarie R KrugDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Dominic V FranceschelliDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Anabel GalanDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Claire M DodsonDepartment of Psychology, The Ohio State University, Columbus, OH, USA.
Kathryn M LenzDepartment of Psychology, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA. Electronic address: lenz.56@osu.edu.
The Ohio State University · USInstitute for Behavioral Medicine · US

Funding

Developmental programming of sex differences in brain innate immune cellsR21MH105826 · NIMH · OHIO STATE UNIVERSITY · PI LENZ, KATHRYN M. · 2015 to 2016
$407k
NIMH NIH HHS R21 MH105826
6 · The paper itself

Abstract

Maternal systemic inflammation increases risk for neurodevelopmental disorders like autism, ADHD, and schizophrenia in offspring. Notably, these disorders are male-biased. Studies have implicated immune system dysfunction in the etiology of these disorders, and rodent models of maternal immune activation provide useful tools to examine mechanisms of sex-dependent effects on brain development, immunity, and behavior. Here, we employed an allergen-induced model of maternal inflammation in rats to characterize levels of mast cells and microglia in the perinatal period in male and female offspring, as well as social, emotional, and cognitive behaviors throughout the lifespan. Adult female rats were sensitized to ovalbumin (OVA), bred, and challenged intranasally on gestational day 15 of pregnancy with OVA or saline. Allergic inflammation upregulated microglia in the fetal brain, increased mast cell number in the hippocampus on the day of birth, and conferred region-, time- and sex- specific changes in microglia measures. Additionally, offspring of OVA-exposed mothers subsequently exhibited abnormal social behavior, hyperlocomotion, and reduced cognitive flexibility. These data demonstrate the long-term effects of maternal allergic challenge on offspring development and provide a basis for understanding neurodevelopmental disorders linked to maternal systemic inflammation in humans.

Indexed as

Prenatal Exposure Delayed EffectsAnimalsCognitionFemaleImmune SystemInflammationMaleOvalbuminPregnancyRatsSocial BehaviorOvalbuminBehaviorImmunologyMast cellsMaternal immune activationMicrogliaSocial play

Identifiers

PMID33798637
PMCPMC8187275
OpenAlexW3141992594

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.