Evidence map›Paper›PMID 33798529›Full record

ReviewJournal of molecular biology2021

Molecular Mechanisms for Bacterial Potassium Homeostasis.

Janina Stautz, Yvonne Hellmich, Michael F Fuss, Jakob M Silberberg, Jason R Devlin, Randy B Stockbridge, Inga Hänelt

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 169 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Extracellular KNature communications · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Susceptibility of the Oral Commensal BacteriumInternational journal of molecular sciences · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Staying in the loop to make ends meet: roles and regulation of GlmR inbioRxiv : the preprint server for biology · 2025
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Janina StautzInstitute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Yvonne HellmichInstitute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Michael F FussInstitute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Jakob M SilberbergInstitute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Jason R DevlinDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
Randy B StockbridgeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, United States. Electronic address: stockbr@umich.edu.
Inga HäneltInstitute of Biochemistry, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address: haenelt@biochem.uni-frankfurt.de.
Goethe University Frankfurt · DEUniversity of Michigan–Ann Arbor · US

Funding

Structural and functional analysis of novel microbial membrane proteinsR35GM128768 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Randy B. Stockbridge · 2018 to 2026
$3.7M
NIGMS NIH HHS R35 GM128768
6 · The paper itself

Abstract

Potassium ion homeostasis is essential for bacterial survival, playing roles in osmoregulation, pH homeostasis, regulation of protein synthesis, enzyme activation, membrane potential adjustment and electrical signaling. To accomplish such diverse physiological tasks, it is not surprising that a single bacterium typically encodes several potassium uptake and release systems. To understand the role each individual protein fulfills and how these proteins work in concert, it is important to identify the molecular details of their function. One needs to understand whether the systems transport ions actively or passively, and what mechanisms or ligands lead to the activation or inactivation of individual systems. Combining mechanistic information with knowledge about the physiology under different stress situations, such as osmostress, pH stress or nutrient limitation, one can identify the task of each system and deduce how they are coordinated with each other. By reviewing the general principles of bacterial membrane physiology and describing the molecular architecture and function of several bacterial K

Indexed as

Bacterial Physiological PhenomenaHomeostasisBacteriaBiological TransportIon TransportMembrane PotentialsPotassiumPotassium ChannelsStructure-Activity RelationshipPotassiumPotassium Channelsbacterial physiologyK(+) transportmembrane potentialprinciples of K(+) transporters and channelsstructural biology

Identifiers

PMID33798529
PMCPMC9041122
OpenAlexW3146941526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.