Evidence map›Paper›PMID 33798465›Full record

SynthesisThe lancet. Diabetes & endocrinology2021

Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.

David A Jolliffe, Carlos A Camargo, John D Sluyter, Mary Aglipay, John F Aloia, Davaasambuu Ganmaa, Peter Bergman, Heike A Bischoff-Ferrari, Arturo Borzutzky, Camilla T Damsgaard and 32 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The lancet. Diabetes & endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 299 papers, 31 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
299citing papers in PubMed, 31 pooled it
59.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

299 citing papers in PubMed, 31 syntheses or guidelines pooled it, 473 citations in OpenAlex.

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  18. Vitamin D for the management of chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2024
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239 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 15 countries.

David A JolliffeBarts and The London School of Medicine and Dentistry, and Asthma UK Centre for Applied Research, Queen Mary University of London, London, UK. Electronic address: d.a.jolliffe@qmul.ac.uk.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
John D SluyterSchool of Population Health, University of Auckland, Auckland, New Zealand.
Mary AglipayDepartment of Pediatrics, St Michael's Hospital, Toronto, ON, Canada.
John F AloiaBone Mineral Research Center, Winthrop University Hospital, Mineola, NY, USA.
Davaasambuu GanmaaDepartment of Nutrition, Harvard TH Chan Shool of Public Health, Boston, MA, USA.
Peter BergmanDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Heike A Bischoff-FerrariDepartment of Geriatric Medicine and Aging Research, University Hospital Zurich, Zurich, Switzerland.
Arturo BorzutzkyDepartment of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Camilla T DamsgaardDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark.
Gal Dubnov-RazExercise, Lifestyle and Nutrition Clinic, Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
Susanna EspositoPaediatric Clinic, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Clare GilhamDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Adit A GindeDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Inbal Golan-TriptoSaban Pediatric Medical Center, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel.
Emma C GoodallDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Cameron C GrantDepartment of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Christopher J GriffithsBarts and The London School of Medicine and Dentistry, and Asthma UK Centre for Applied Research, Queen Mary University of London, London, UK.
Anna Maria HibbsDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA; University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Wim JanssensUniversitair Ziekenhuis Leuven, Leuven, Belgium.
Anuradha Vaman KhadilkarHirabai Cowasji Jehangir Medical Research Institute, Maharashtra, India.
Ilkka LaaksiFaculty of Medicine and Health Technology, University of Tampere, Tampere, Finland; Centre for Military Medicine, Helsinki, Finland.
Margaret T LeeDivision of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Columbia University Medical Center, New York, NY USA.
Mark LoebDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Jonathon L MaguireDepartment of Pediatrics, St Michael's Hospital, Toronto, ON, Canada.
Paweł MajakDepartment of Pediatric Pulmonology, Medical University of Lodz, Lodz, Poland.
David T MaugerDepartment of Statistics, The Pennsylvania State University, Hershey, PA, USA.
Semira Manaseki-HollandDepartment of Public Health, Epidemiology and Biostatistics, Institute of Applied Health Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
David R MurdochDepartment of Pathology, University of Otago, Christchurch, New Zealand.
Akio NakashimaJikei University School of Medicine, Tokyo, Japan.
Rachel E NealePopulation Health Department, QIMR Berghofer Medical Research Institute, QLD, Australia.
Hai PhamPopulation Health Department, QIMR Berghofer Medical Research Institute, QLD, Australia.
Christine RakeDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Judy R ReesDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Jenni RosendahlChildren's Hospital, Pediatric Research Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Robert ScraggSchool of Population Health, University of Auckland, Auckland, New Zealand.
Dheeraj ShahDepartment of Paediatrics, University College of Medical Sciences, Delhi, India.
Yoshiki ShimizuFANCL Research Institute, FANCL Corporation, Yokohama, Japan.
Steve Simpson-YapNeuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Geeta Trilok-KumarInstitute of Home Economics, University of Delhi, New Delhi, India.
Mitsuyoshi UrashimaJikei University School of Medicine, Tokyo, Japan.
Adrian R MartineauBarts and The London School of Medicine and Dentistry, and Asthma UK Centre for Applied Research, Queen Mary University of London, London, UK. Electronic address: a.martineau@qmul.ac.uk.
University of Auckland · NZAsthma UK · GBHarvard University · USJikei University School of Medicine · JPLondon School of Hygiene & Tropical Medicine · GBQIMR Berghofer Medical Research Institute · AUSt. Michael's Hospital · CAColumbia University Irving Medical Center · USDartmouth College · USEdmond and Lily Safra Children's Hospital · ILFanuc (Japan) · JPFinnish Defence Forces · FIHelsinki University Hospital · FIImpact · CAJehangir Hospital · INKarolinska Institutet · SEMcMaster University · CAMedical University of Lodz · PLPennsylvania State University · USPontificia Universidad Católica de Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis.

methodsFor this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov registry for studies listed from database inception to May 1, 2020. Double-blind RCTs of vitamin D

findingsWe identified 1528 articles, of which 46 RCTs (75 541 participants) were eligible. Data for the primary outcome were obtained for 48 488 (98·1%) of 49 419 participants (aged 0-95 years) in 43 studies. A significantly lower proportion of participants in the vitamin D supplementation group had one or more ARIs (14 332 [61·3%] of 23 364 participants) than in the placebo group (14 217 [62·3%] of 22 802 participants), with an OR of 0·92 (95% CI 0·86-0·99; 37 studies; I

interpretationDespite evidence of significant heterogeneity across trials, vitamin D supplementation was safe and overall reduced the risk of ARI compared with placebo, although the risk reduction was small. Protection was associated with administration of daily doses of 400-1000 IU for up to 12 months, and age at enrolment of 1·00-15·99 years. The relevance of these findings to COVID-19 is not known and requires further investigation.

fundingNone.

Indexed as

Dietary SupplementsHumansRandomized Controlled Trials as TopicRespiratory Tract InfectionsTreatment OutcomeVitamin DVitamin D

Identifiers

PMID33798465
OpenAlexW3145956627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.