Evidence map›Paper›PMID 33798426›Full record

ArticleStructure (London, England : 1993)2021

Tête-à-tête with CtBP dimers.

Ana-Maria Raicu, Kalynn M Bird, David N Arnosti

Abstract readComment
In one paragraph

Article in Structure (London, England : 1993), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ana-Maria RaicuCell and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI, USA.
Kalynn M BirdDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
David N ArnostiDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA. Electronic address: arnosti@msu.edu.

Funding

Biochemical, Genomic and Computational Analysis of Transcriptional RepressionR01GM124137 · NIGMS · MICHIGAN STATE UNIVERSITY · PI ARNOSTI, DAVID N · 2017 to 2020
$1.2M
NIGMS NIH HHS R01 GM124137
6 · The paper itself

Abstract

Jecrois et al. (2020) use cryoelectron microscopy to illuminate the tetrameric conformation of the CtBP2 transcriptional corepressor, a protein frequently overexpressed in human cancers. The in vivo functional characterization of tetramer-destabilizing mutants indicates that tetramerization is a physiologically important process, critical for CtBP control of gene regulation and cell migration.

Indexed as

Alcohol OxidoreductasesDNA-Binding ProteinsCell MovementCo-Repressor ProteinsCryoelectron MicroscopyHumansTranscription FactorsAlcohol OxidoreductasesCo-Repressor ProteinsCTBP2 protein, humanDNA-Binding ProteinsTranscription Factors

Identifiers

PMID33798426
PMCPMC9069854

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.