Evidence map›Paper›PMID 33798420›Full record

ArticleCell stem cell2021

High-fat diet activates a PPAR-δ program to enhance intestinal stem cell function.

Semir Beyaz, Miyeko D Mana, Ömer H Yilmaz

Open access · bronzeAbstract readLetter
In one paragraph

Article in Cell stem cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Diet-induced chromatin states influence intestinal stem cell memory.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Semir BeyazCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. Electronic address: beyaz@cshl.edu.
Miyeko D ManaThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.
Ömer H YilmazThe David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: ohyilmaz@mit.edu.
Cold Spring Harbor Laboratory · USHarvard University · USKoch Institute for Integrative Cancer Research At MIT · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Andreea O'Connell · 1985 to 2026
$93.9M
Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunctionR01DK126545 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLOVERPRIS, HENRIK, KWON, DOUGLAS · 2020 to 2024
$3.6M
Developing high-throughput genetic perturbation strategies for single cells in cancer organoidsU01CA250554 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BERGER, BONNIE, YILMAZ, OMER · 2020 to 2022
$2.8M
Dietary control of stem cells in physiology and cancerR01CA211184 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YILMAZ, OMER · 2017 to 2021
$2.0M
Metabolic and epigenetic drivers of stem cells in obesity and cancerK22CA241083 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MANA, MIYEKO · 2020 to 2022
$531k
Optimizing Gram-positive bacteria as a candidate for targeted anti-tumor therapyF32CA254314 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHUSTER, BENTLEY M. · 2020 to 2022
$151k
NCI NIH HHS F32 CA254314NCI NIH HHS K22 CA241083NCI NIH HHS P30 CA014051NCI NIH HHS P30 CA045508NCI NIH HHS R01 CA211184NCI NIH HHS U01 CA250554NIDDK NIH HHS R01 DK126545
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

PPAR deltaStem CellsDiet, High-FatHumansObesityPPAR delta

Identifiers

PMID33798420
PMCPMC8875728
OpenAlexW3141059856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.