ArticleNeuron2021
Nonlinear spatial integration in retinal bipolar cells shapes the encoding of artificial and natural stimuli.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 43 citations in OpenAlex.
- Temporal prediction captures retinal spiking responses across animal species.Nature communications · 2026Article
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Filter-based models of suppression in retinal ganglion cells: Comparison and generalization across species and stimuli.PLoS computational biology · 2025Article
- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
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- The sodium-bicarbonate cotransporter Slc4a5 mediates feedback at the first synapse of vision.Neuron · 2024Article
- Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.PLoS computational biology · 2024Article
- A recurrent neural circuit inbioRxiv : the preprint server for biology · 2024Article
- Distributed feature representations of natural stimuli across parallel retinal pathways.Nature communications · 2024Article
- Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management.Chemical reviews · 2023Review
- Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.Nature communications · 2023Article
- Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- Suppression without inhibition: how retinal computation contributes to saccadic suppression.Communications biology · 2022Article
- Article
- Simple model for encoding natural images by retinal ganglion cells with nonlinear spatial integration.PLoS computational biology · 2022Article
- Enhancing the dark side: asymmetric gain of cone photoreceptors underpins their discrimination of visual scenes based on skewness.The Journal of physiology · 2022Article
- Dissecting cascade computational components in spiking neural networks.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retina dissects the visual scene into parallel information channels, which extract specific visual features through nonlinear processing. The first nonlinear stage is typically considered to occur at the output of bipolar cells, resulting from nonlinear transmitter release from synaptic terminals. In contrast, we show here that bipolar cells themselves can act as nonlinear processing elements at the level of their somatic membrane potential. Intracellular recordings from bipolar cells in the salamander retina revealed frequent nonlinear integration of visual signals within bipolar cell receptive field centers, affecting the encoding of artificial and natural stimuli. These nonlinearities provide sensitivity to spatial structure below the scale of bipolar cell receptive fields in both bipolar and downstream ganglion cells and appear to arise at the excitatory input into bipolar cells. Thus, our data suggest that nonlinear signal pooling starts earlier than previously thought: that is, at the input stage of bipolar cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.