ArticleHead and neck pathology2021
Clinicopathologic Characteristics of Young Patients with Oral Squamous Cell Carcinoma.
Article in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Prognostic factors in young patients with oral cavity cancer: a systematic review and meta-analysis of 24 studies.Frontiers in oncology · 2026Pooled it
- The prognostic significance of tertiary lymphoid structures in oral squamous cell carcinomas: a systematic review.Frontiers in oral health · 2024Pooled it
- Global Epidemiological Insights: Temporal Trends and Disparities in Oral Cavity Cancer Mortality in the United States, 1999-2024.International dental journal · 2026Article
- Modulation ofInternational journal of molecular sciences · 2026Article
- Programmed cell death ligand 1(PD-L1) association in metastatic and non-metastatic oral squamous cell carcinoma: clinicopathologic and immunohistochemical study.Scientific reports · 2026Article
- Early-Onset Oral Squamous Cell Carcinoma: Emerging Biological Insights, Risk Factors and Clinical Implications.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Review
- Mendelian Randomization and ScTranscriptomics Reveal a Lipid Low Malignant Cells Driving Immunosuppression and Matrix Remodeling in Oral squamous cell carcinoma.International dental journal · 2026Article
- Cell Proliferation, DNA Damage, and Apoptosis in Oral Leukoplakia and Oral Squamous Cell Carcinoma in Young Patients: A Comparative Immunohistochemical Study.Head and neck pathology · 2025Article
- Clinicopathologic characteristics of young patients with lip squamous cell carcinoma: a retrospective study.Medicina oral, patologia oral y cirugia bucal · 2024Article
- Leukoplakia and erythroplakia in youngers versus older individuals: a clinicopathological retrospective study.Medicina oral, patologia oral y cirugia bucal · 2024Article
- Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma.Frontiers in oncology · 2024Article
- Article
- Oral squamous cell carcinoma - do we always need elective neck dissection? evaluation of clinicopathological factors of greatest prognostic significance: a cross-sectional observational study.Frontiers in oncology · 2023Review
- Vascular and Neural Invasion in Oral Squamous Cell Carcinoma: A Study in an Iranian Population.Advanced biomedical research · 2023Article
- Facial-submental island flap for reconstruction of hemitongue defects in young, middle-aged and elderly patients with early and middle stage oral tongue squamous cell carcinoma.Head & face medicine · 2022Article
- Immunoexpression of p53 mutant-type in Iranian patients with primary and recurrence oral squamous cell carcinoma.European journal of translational myology · 2022Article
- Defining biomarkers in oral cancer according to smoking and drinking status.Frontiers in oncology · 2022Article
- Oral Cavity Squamous Cell Carcinoma in Young Patients: A Multi-Institutional Study of the Canadian Head & Neck Collaborative Research Initiative.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Oral squamous cell carcinoma (OSCC) occasionally occurs in young patients and is likely to be distinct from OSCC in older patients. In this retrospective study, we described the clinicopathologic features and outcome of 150 OSCCs that were diagnosed in patients 40-year-old or younger. Most patients (63%) were non-smokers. The most common site of the primary tumor was oral tongue (n = 131, 87%), followed by gingiva (n = 9), buccal mucosa (n = 8) and lip (n = 2). The median patients' age at presentation was 34 (range: 16-40). Seven patients (5%) had Fanconi anemia with the gingiva being the most common location (4/7, 57%). All OSCCs were of keratinizing type. All cases tested for high-risk HPV (n = 34) were negative. On univariate analysis, high tumor budding was associated with decreased overall survival (OS) and distant metastasis free survival (DMFS), pattern of invasion correlated with OS and tumors with high stromal tumor infiltrating lymphocytes (sTIL) were associated with improved locoregional recurrence free survival (LRFS). Compared with patients 31 to 40-year-old, OSCC in the younger group was associated with significant less alcohol consumption (p = 0.011) and decreased DSS (p = 0.003) and DMFS (p = 0.023). On multivariate analysis, younger age (30 years or younger) was an independent prognostic factor for worse OS and DSS, whereas histologic grade was an independent prognostic factor for DSS. In summary, most OSCC in young patients occurred in non-smokers and did not occur in association with Fanconi anemia. Independent prognostic factors included age at presentation (30 years or younger) for OS and DSS, and histologic grade for DSS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.