Evidence map›Paper›PMID 33797677›Full record

ArticleJournal of assisted reproduction and genetics2021

Sixth grade academic achievement among children conceived with IVF: a population-based study in Texas, USA.

Barbara Luke, Morton B Brown, Mary K Ethen, Mark A Canfield, Stephanie Watkins, Ethan Wantman, Kevin J Doody

Open access · greenAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Barbara LukeDepartment of Obstetrics, Gynecology, and Reproductive Biology, College of Human Medicine, Michigan State University, East Fee Hall, Room 628, 965 Wilson Road, East Lansing, MI, USA. lukeb@msu.edu.ORCID http://orcid.org/0000-0002-0405-8133
Morton B BrownDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Mary K EthenBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, USA.
Mark A CanfieldBirth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, USA.
Stephanie WatkinsNovo Nordisk, Plainsboro, NJ, USA.
Ethan WantmanRedshift Technologies, Inc., New York, NY, USA.
Kevin J DoodyCenter for Assisted Reproduction, Bedford, TX, USA.
Texas Department of State Health Services · USCARE Fertility · USMichigan State University · USNovo Nordisk (United States) · USUniversity of Michigan · US

Funding

Assisted Reproduction and Child Health: Risk of Birth Defects, Mortality, and Effect on Grade School PerformanceR01HD084377 · NICHD · MICHIGAN STATE UNIVERSITY · PI LUKE, BARBARA JOAN · 2016 to 2020
$2.6M
NICHD NIH HHS R01 HD084377
6 · The paper itself

Abstract

purposeTo compare academic achievement in reading and mathematics at the end of sixth grade and progress from third to sixth grade by children conceived with in vitro fertilization (IVF) to those conceived naturally.

methodsThis was a retrospective population-based cohort study of IVF-conceived singleton and twin children who took the 3rd grade and 6th grade public school standardized reading and mathematics testing in Texas.

resultsThere were 6623 children with reading scores in both the third and sixth grades and 6374 children with mathematics scores in both the third and sixth grades. Mean (± SE) scaled test scores for IVF and control singleton children for reading were 1544.6 ± 3.4 and 1527.7 ± 1.9, respectively, in third grade and 1701.2 ± 3.6 and 1681.0 ± 2.0, respectively, in sixth grade; for mathematics, the scores were 1564.4 ± 3.7 and 1548.9 ± 2.1, respectively, in third grade and 1774.0 ± 4.2 and 1752.0 ± 2.3, respectively, in sixth grade. In multivariate models, singleton IVF children scored significantly higher than control children in reading and mathematics, averaging 17.7 ± 4.0 points and 20.1 ± 4.1 points higher, respectively, in reading in third and sixth grades and 17.8 ± 4.4 points and 25.0 ± 4.8 points higher, respectively, in mathematics in third and sixth grades.

conclusionsChildren conceived with IVF and aged 8-9 years and aged 10-12 years performed as well on third and sixth grade reading and mathematics assessments as their counterparts conceived naturally.

Indexed as

Academic SuccessFertilization in VitroReproductive Techniques, AssistedAdolescentAdultChildCohort StudiesFemaleHumansMaleMathematicsReadingTexasTwinsYoung AdultAcademic achievementEnd-of-grade testingIVF

Identifiers

PMID33797677
PMCPMC8266932
OpenAlexW3144521433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.