ArticleInternational journal of bipolar disorders2021
Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia.
Article in International journal of bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 18 citations in OpenAlex.
- Inter-network Effective Connectivity During an Emotional Working Memory Task in Two Independent Samples of Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Prior Trial Effects on Working Memory in Schizophrenia, Bipolar Disorder, and Healthy Control Individuals.JAMA psychiatry · 2026Article
- ERP Decoding Analysis of Visual Working Memory Processes in Schizophrenia.Alpha psychiatry · 2026Article
- Impaired visuospatial working memory but preserved attentional control in bipolar disorder.Psychological medicine · 2025Article
- Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- External cues improve visual working memory encoding in the presence of salient distractors in schizophrenia.Psychological medicine · 2024Article
- Working Memory in People with Schizophrenia.Current topics in behavioral neurosciences · 2023Article
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Authors and funding
9 authors at 1 institution in 2 countries.
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Abstract
backgroundImpaired working memory is a core cognitive deficit in both bipolar disorder and schizophrenia. Its study might yield crucial insights into the underpinnings of both disorders on the cognitive and neurophysiological level. Visual working memory capacity is a particularly promising construct for such translational studies. However, it has not yet been investigated across the full spectrum of both disorders. The aim of our study was to compare the degree of reductions of visual working memory capacity in patients with bipolar disorder (PBD) and patients with schizophrenia (PSZ) using a paradigm well established in cognitive neuroscience.
methods62 PBD, 64 PSZ, and 70 healthy controls (HC) completed a canonical visual change detection task. Participants had to encode the color of four circles and indicate after a short delay whether the color of one of the circles had changed or not. We estimated working memory capacity using Pashler's K.
resultsWorking memory capacity was significantly reduced in both PBD and PSZ compared to HC. We observed a small effect size (r = .202) for the difference between HC and PBD and a medium effect size (r = .370) for the difference between HC and PSZ. Working memory capacity in PSZ was also significantly reduced compared to PBD with a small effect size (r = .201). Thus, PBD showed an intermediate level of impairment.
conclusionsThese findings provide evidence for a gradient of reduced working memory capacity in bipolar disorder and schizophrenia, with PSZ showing the strongest degree of impairment. This underscores the importance of disturbed information processing for both bipolar disorder and schizophrenia. Our results are compatible with the cognitive manifestation of a neurodevelopmental gradient affecting bipolar disorder to a lesser degree than schizophrenia. They also highlight the relevance of visual working memory capacity for the development of both behavior- and brain-based transdiagnostic biomarkers.
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