Evidence map›Paper›PMID 33797416›Full record

ArticleJournal of biomedical research2020

A transgenic pig model expressing a CMV-ZsGreen1 reporter across an extensive array of tissues.

Amy T Desaulniers, Rebecca A Cederberg, Elizabeth P Carreiro, Channabasavaiah B Gurumurthy, Brett R White

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amy T DesaulniersDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA.
Rebecca A CederbergDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA.
Elizabeth P CarreiroDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA.
Channabasavaiah B GurumurthyDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5930, USA.
Brett R WhiteDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA.
University of Nebraska–Lincoln · USUniversity of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since genetic engineering of pigs can benefit both biomedicine and agriculture, selecting a suitable gene promoter is critically important. The cytomegalovirus (CMV) promoter, which can robustly drive ubiquitous transgene expression, is commonly used at present, yet recent reports suggest tissue-specific activity in the pig. The objective of this study was to quantify ZsGreen1 protein (in lieu of CMV promoter activity) in tissues from pigs harboring a CMV-ZsGreen1 transgene with a single integration site. Tissue samples (

Indexed as

biomedical modelCMV promotergene expression profilinggenome editingZsGreen1

Identifiers

PMID33797416
PMCPMC8038527
OpenAlexW3145034858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.