ArticleTherapeutic innovation & regulatory science2021
Randomized Single-Case Intervention Designs and Analyses for Health Sciences Researchers: A Versatile Clinical Trials Companion.
Article in Therapeutic innovation & regulatory science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Shockwave therapy in persons with a spinal cord injury and spasticity: A multiple single-case experimental design study.The journal of spinal cord medicine · 2025Trial
- The Effects of Video Visual Scene Displays on the Symbolic Communication of Preschool Children with Neurodevelopmental Disabilities and Their Peers in a Shared Video Activity.Behavioral sciences (Basel, Switzerland) · 2026Article
- A tutorial for software options to aid in assessing functional relations in single-case experimental designs.Behavior research methods · 2026Article
- Using Behavioural Skills Training with Healthcare Staff to Promote Greater Independence for People Living with Dementia: A Randomised Single-Case Experimental Design.Behavioral sciences (Basel, Switzerland) · 2025Article
- The role of single case experimental designs in evidence creation in rehabilitation.European journal of physical and rehabilitation medicine · 2024Article
- Article
- Protocol for single case experimental design for yoga and sleep quality and inflammation: A two-hit model of sleep intervention.Contemporary clinical trials communications · 2022Article
- Honoring Uncontrolled Events: Commentary on Slocum et al.Perspectives on behavior science · 2022Article
- Examining and Enhancing the Methodological Quality of Nonconcurrent Multiple-Baseline Designs.Perspectives on behavior science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAn expository note introduces health sciences researchers to randomized single-case intervention designs, an adaptation of interrupted time-series methodology, and the staple of a scientifically credible small-sample research paradigm.
methodsDetailed examples illustrating two different randomized single-case procedures are presented to highlight the techniques' advantages relative to small-sample nonparametric procedures that are commonly applied in the medical and health sciences fields.
resultsNumerous positive outcomes, based on both statistical simulation studies and actual intervention research investigations, support the applicability and value of these procedures.
conclusionRandomized single-case intervention designs are recommended for consideration by health sciences researchers.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.