Evidence map›Paper›PMID 33796956›Full record

ArticleEJNMMI research2021

Region- and voxel-based quantification in human brain of [

Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L Morse, Jose A Montero Santamaria, Mohammad B Haskali, Sami S Zoghbi, Victor W Pike, Robert B Innis, Paolo Zanotti-Fregonara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Radiosynthesis and evaluation of a carbon-11 labeled PET ligand for imaging of O-GlcNAcase.American journal of nuclear medicine and molecular imaging · 2025
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jae-Hoon LeeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA. jae-hoon.lee@nih.gov.ORCID http://orcid.org/0000-0002-9898-9886
Mattia VeroneseDepartment of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Cheryl L MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Jose A Montero SantamariaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Mohammad B HaskaliMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
Paolo Zanotti-FregonaraMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Clinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002852NIMH NIH HHS ZIAMH002793NIMH NIH HHS ZIAMH002852
6 · The paper itself

Abstract

backgroundPrevious studies found that the positron emission tomography (PET) radioligand [

methodsThe current study reanalyzed data from a previous study of 10 healthy volunteers who underwent both test and retest PET scans with [

resultsLogan and MA1 generated parametric images of good visual quality and their total distribution volume (V

conclusionsCompared to SA and IRF, Logan and MA1 are more suitable alternatives to 2TCM for quantifying [

Indexed as

[18F]LSN3316612O-GlcNAcaseParametric imagePositron emission tomographyTau

Identifiers

PMID33796956
PMCPMC8017047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.