Evidence map›Paper›PMID 33796919›Full record

ArticleEuropean journal of nutrition2021

Bifidobacterium Lactis Probio-M8 regulates gut microbiota to alleviate Alzheimer's disease in the APP/PS1 mouse model.

Jianing Cao, William Kwame Amakye, Chunli Qi, Xiaojun Liu, Jie Ma, Jiaoyan Ren

Abstract read
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In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jianing CaoSchool of Food Science and Engineering, South China University of Technology, 381 Wu Shan Road, Guangzhou, 510641, China.
William Kwame AmakyeSchool of Food Science and Engineering, South China University of Technology, 381 Wu Shan Road, Guangzhou, 510641, China.
Chunli QiSchool of Food Science and Engineering, South China University of Technology, 381 Wu Shan Road, Guangzhou, 510641, China.
Xiaojun LiuBeijing Scitop Bio-Tech Co. Ltd., Beijing, China.
Jie MaBeijing Scitop Bio-Tech Co. Ltd., Beijing, China.
Jiaoyan RenSchool of Food Science and Engineering, South China University of Technology, 381 Wu Shan Road, Guangzhou, 510641, China. jyren@scut.edu.cn.ORCID http://orcid.org/0000-0002-2063-601X
South China University of Technology · CN

Funding

Fundamental Research Funds for the Central Universities 2019KZ01Key Research and Development Project of Guangdong Province (CN) 2019B020210002National Key R&D Program of China 2018YFD0901101National Natural Science Foundation of China (CN) 31671804Natural Science Foundation of Guangdong Province (CN) 2019A1515012230
6 · The paper itself

Abstract

purposeStudies have shown that Alzheimer's disease is associated with significant alterations in the gut microbiota. But the effect of probiotics and/or prebiotics on Alzheimer's disease still remains to be explored. The aim of this study was to determine whether Bifidobacterium Lactis Probio-M8 could alleviate Alzheimer's disease pathophysiologies in the APP/PS1 transgenic mouse model.

methods4-month old APP/PS1 mice were randomly put into two groups and fed with either Probio-M8 or saline water for 45 days. Fecal samples of mice were collected at the beginning and the end of the treatment period to determine the composition of the gut microbiota via 16S ribosomal RNA sequencing technology. The number and size of Aβ plaques in the brain were quantified. In addition, Y maze, novel object recognition and nest building were employed to access cognitive function in the 8-months old APP/PS1 mice at the end of the treatment period.

conclusionOur results demonstrated that Probio-M8 reduced Aβ plaque burden in the whole brain and protected against gut microbiota dysbiosis. Furthermore, Probio-M8 could alleviate cognitive impairment in the APP/PS1 mouse.

Indexed as

Alzheimer DiseaseBifidobacterium animalisGastrointestinal MicrobiomeAmyloid beta-PeptidesAnimalsMiceMice, TransgenicAmyloid beta-PeptidesAPP/PS1 mouseAβBifidobacterium LactisGut microbiotaProbio-M8

Identifiers

PMID33796919
OpenAlexW3147786781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.