Evidence map›Paper›PMID 33796917›Full record

ArticleCancer immunology, immunotherapy : CII2021

Clinically applicable CD34

Jesper van Eck van der Sluijs, Diede van Ens, Soley Thordardottir, Denise Vodegel, Inge Hermens, Anniek B van der Waart, J H Frederik Falkenburg, Michel G D Kester, Iris de Rink, Mirjam H M Heemskerk and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Human CD34Frontiers in immunology · 2024
    Article
  9. Guidelines for mouse and human DC generation.European journal of immunology · 2023
    Article
  10. Review
  11. Review
  12. Human CD34Cellular and molecular life sciences : CMLS · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Dendritic Cells and Cancer Immunotherapy: The Adjuvant Effect.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Jesper van Eck van der SluijsDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-3136-7799
Diede van EnsDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-7273-4896
Soley ThordardottirDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-2969-4088
Denise VodegelDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-4534-2907
Inge HermensDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-2890-3231
Anniek B van der WaartDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-5986-3060
J H Frederik FalkenburgDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-9819-4813
Michel G D KesterDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-8960-7348
Iris de RinkGenomics Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1850-1340
Mirjam H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-6320-9133
Jannie BorstDepartment of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-8043-5009
Nicolaas P M SchaapDepartment of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-7696-4752
Joop H JansenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-9459-568X
Yanling Xiao *Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-1755-1709
Harry Dolstra *Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-3998-687X
Willemijn Hobo *Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. Willemijn.Hobo@radboudumc.nl.ORCID http://orcid.org/0000-0002-8206-8185
Radboud University Nijmegen · NLLeiden University Medical Center · NLThe Netherlands Cancer Institute · NL

Funding

Health-Holland Foundation LSHM18048KWF Kankerbestrijding 10351KWF Kankerbestrijding 11079
6 · The paper itself

Abstract

Allogeneic stem cell transplantation (alloSCT), following induction chemotherapy, can be curative for hemato-oncology patients due to powerful graft-versus-tumor immunity. However, disease recurrence remains the major cause of treatment failure, emphasizing the need for potent adjuvant immunotherapy. In this regard, dendritic cell (DC) vaccination is highly attractive, as DCs are the key orchestrators of innate and adaptive immunity. Natural DC subsets are postulated to be more powerful compared with monocyte-derived DCs, due to their unique functional properties and cross-talk capacity. Yet, obtaining sufficient numbers of natural DCs, particularly type 1 conventional DCs (cDC1s), is challenging due to low frequencies in human blood. We developed a clinically applicable culture protocol using donor-derived G-CSF mobilized CD34

Indexed as

Antigen PresentationAntigens, CD34Cell Culture TechniquesCross-PrimingDendritic CellsHematopoietic Stem CellsHumansKiller Cells, NaturalLymphocyte ActivationT-LymphocytesAntigens, CD34CD34+ hematopoietic progenitor cellsClinical applicationDendritic cellsNK cellsT cellsVaccination

Identifiers

PMID33796917
PMCPMC8505305
OpenAlexW3145249441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.