ReviewPediatric nephrology (Berlin, Germany)2022
Molecular mechanisms altering tubular calcium reabsorption.
Review in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Random Urinary Calcium/Creatinine Ratio as a Predictor of Dehydration in Hypercalcemic and Normocalcemic Patients.Journal of clinical medicine · 2026Article
- Disruption of Claudin-2 and Trpv6 Results in Hypocalcemia, Hypercalciuria, and Altered Bone Microarchitecture in Mice.Acta physiologica (Oxford, England) · 2026Article
- Urolithiasis in Children-Clinical Picture, Pathogenesis, and Diagnostic Approach.Biomolecules · 2026Review
- Urinary Calcium and Phosphorus Excretion in Vitamin D-Sufficient Preterm Infants: Establishing Age-Specific Normative Data.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Review
- Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance.The Journal of physiology · 2024Article
- A successful conclusion to the long search for TRPV5 pathogenic variants in monogenic hypercalciuria.European journal of human genetics : EJHG · 2024Article
- Decreased calcium permeability caused by biallelic TRPV5 mutation leads to autosomal recessive renal calcium-wasting hypercalciuria.European journal of human genetics : EJHG · 2024Article
- Understanding formation processes of calcareous nephrolithiasis in renal interstitium and tubule lumen.Journal of cellular and molecular medicine · 2024Review
- Nephrocalcinosis in a 3-year-old child with hypocalcemia: Answers.Pediatric nephrology (Berlin, Germany) · 2023Article
- 24-h Urinary Calcium Excretion and Renal Outcomes in Hospitalized Patients with and without Chronic Kidney Disease.Journal of clinical medicine · 2023Article
- Dietary advices for patients with metabolic syndrome and obesity.World journal of urology · 2023Article
- Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir.Frontiers in cell and developmental biology · 2023Article
- Regulation of 1 and 24 hydroxylation of vitamin D metabolites in the proximal tubule.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- FAM111A is dispensable for electrolyte homeostasis in mice.Scientific reports · 2022Article
- Calcium and Vitamin D Supplementation and Their Association with Kidney Stone Disease: A Narrative Review.Nutrients · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The majority of calcium filtered by the glomerulus is reabsorbed along the nephron. Most is reabsorbed from the proximal tubule (> 60%) via a paracellular pathway composed of the tight junction proteins claudins-2 and -12, a process driven by sodium and consequently water reabsorption. The thick ascending limb reabsorbs the next greatest amount of calcium (20-25%), also by a paracellular pathway composed of claudins-16 and -19. This pathway is regulated by the CaSR, whose activity increases the expression of claudin-14, a protein that blocks paracellular calcium reabsorption. The fine tuning of urinary calcium excretion occurs in the distal convoluted and connecting tubule by a transcellular pathway composed of the apical calcium channel TRPV5, the calcium shuttling protein calbindin-D
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Registered trials
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