Evidence map›Paper›PMID 33796800›Full record

ArticleJournal of immunology and regenerative medicine2021

Phagocytosis of apoptotic endothelial cells reprograms macrophages in skin wounds.

Mingyuan Xu, Zhenlong Chen, Kevin Chen, Da Ma, Lin Chen, Luisa A DiPietro

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology and regenerative medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Heliyon · 2022
    Article
  5. Angiogenesis in Wound Repair: Too Much of a Good Thing?Cold Spring Harbor perspectives in biology · 2022
    Review
  6. Review
  7. Article
  8. Review
  9. Macrophages in Healing Wounds: Paradoxes and Paradigms.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mingyuan XuDepartment of Plastic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhenlong ChenDepartments of Anesthesiology, College of Medicine, University of Illinois at Chicago, Chicago, USA.
Kevin ChenCenter for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, USA.
Da MaGuangdong Provincial Key Laboratory of Stomatology, Stomatological Hospital, Guanghua School of Stomatology, SunYat-sen University, Guangzhou, Guangdong, China.
Lin ChenCenter for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, USA.
Luisa A DiPietroCenter for Wound Healing and Tissue Regeneration, University of Illinois at Chicago, Chicago, USA.
University of Illinois Chicago · USSun Yat-sen University · CNZhejiang University · CN

Funding

ANGIOGENESIS IN WOUND REPAIRR01GM050875 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIPIETRO, LUISA A · 1999 to 2020
$6.6M
Complexity and the Wound Healing ResponseR35GM139603 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIPIETRO, LUISA A · 2021 to 2025
$1.7M
NIGMS NIH HHS R01 GM050875NIGMS NIH HHS R35 GM139603
6 · The paper itself

Abstract

In healing wounds, the regression of blood vessels during the resolution phase creates a significant number of apoptotic endothelial cells (ApoECs). Surprisingly few studies have investigated the fate of apoECs in wounds, or the consequence of their removal. The current study employed both

Indexed as

apoptosisendothelial cellmacrophagephagocytosisskinwound healing

Identifiers

PMID33796800
PMCPMC8009329
OpenAlexW3128922180

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.