Evidence map›Paper›PMID 33796796›Full record

ArticleClinical and translational radiation oncology2021

Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise.

Joeri Mul, Patrick Melchior, Enrica Seravalli, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Kristin Gurtner, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational radiation oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 12 institutions in 7 countries.

Joeri MulPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Patrick MelchiorDept. of Radiation Oncology, Saarland University Hospital, Homburg, Germany.
Enrica SeravalliDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Daniel SaundersDept. of Clinical Oncology, The Christie Hospital, Manchester, United Kingdom.
Stephanie BolleDept. of Radiation Oncology, Gustave Roussy, Villejuif, France.
Alison L CameronBristol Cancer Institute, University Hospitals, Bristol, United Kingdom.
Kristin GurtnerDept. of Radiation Oncology, University Hospital Carl Gustav Carus, Dresden, Germany.
Semi HarrabiDept. of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Yasmin Lassen-RamshadDept. of Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
Naomi LavanSt. Luke's Radiation Oncology Network, Dublin, Ireland.
Henriette MagelssenDept. of Oncology, Oslo University Hospital, Oslo, Norway.
Henry MandevilleDept. of Clinical Oncology, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.
Tom BoterbergDept. of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
Petra S KroonDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Alexis N T J KotteDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Bianca A W HoebenPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Peter S N van RossumDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Martine van GrotelPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Norbert GrafDept. of Pediatric Oncology, Saarland University Hospital, Homburg, Germany.
Marry M van den Heuvel-EibrinkPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Christian RübeDept. of Radiation Oncology, Saarland University Hospital, Homburg, Germany.
Geert O JanssensPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Princess Máxima Center · NLUniversity Medical Center Utrecht · NLSaarland University · DEAarhus University Hospital · DKGhent University Hospital · BEHeidelberg University · DEInstitut Gustave Roussy · FROslo University Hospital · NORoyal Marsden NHS Foundation Trust · GBThe Christie Hospital · GBUniversity Hospital Carl Gustav Carus · DEUniversity Hospitals Bristol NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeRecently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance. MATERIALS AND

methodsSix pediatric renal cancer cases were transferred to ten radiation oncologists from seven European countries ('participants'). These participants delineated the pre- and postoperative Gross Tumor Volume (GTV

resultsA total of 57/60 delineation sets were completed. The median DSC

conclusionThis international multicenter delineation exercise demonstrates that the new consensus for highly-conformal postoperative flank target volume delineation leads to geometrical variation among participants. Moreover, standardized review showed an unacceptable delineation variation in the majority of the participants. These findings strongly suggest the need for additional training and centralized pre-treatment review when this target volume delineation approach is implemented on a larger scale.

Indexed as

AA, abdominal aortaAP/PA, Anterior-Posterior/Posterior-AnteriorCT, Computed TomographyCTV-N, Clinical Target Volume of the lymph node areaCTV-T, Clinical Target Volume of the primary TumorDICOM, Digital Imaging and Communications in MedicineDSC, Dice Similarity CoefficientFlank target volumeGTVpre/post, pre- and postoperative Gross Tumor Volume respectivelyHighly-conformal radiotherapyHR, High-RiskIGRT, Image-Guided RadiotherapyIMRT, Intensity-Modulated RadiotherapyInter-clinician variationIR, Intermediate-RiskIVC, inferior vena cavaMRI, Magnetic Resonance Imagingn.a., not applicableOAR, organs at riskpart, participantPediatric renal tumorsQuality assuranceref, referenceRTOG, Radiation Oncology GroupRT, radiotherapyRTSG, Renal Tumor Study GroupSIOP, International Society for Pediatric OncologyTVintersect, intersect target volumeTVref, reference target volumesWilms tumorWT, Wilms’ tumor

Identifiers

PMID33796796
PMCPMC7995478
OpenAlexW3134804019

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.