Evidence map›Paper›PMID 33796553›Full record

SynthesisSkin appendage disorders2021

The Impact of Nail Psoriasis and Treatment on Quality of Life: A Systematic Review.

Claire R Stewart, Leah Algu, Rakhshan Kamran, Cameron F Leveille, Khizar Abid, Charlene Rae, Shari R Lipner

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Skin appendage disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
  7. Article
  8. Unveiling Psoriasis: Delving into Pathogenesis, Treatment Breakthroughs, and Patent Trends.Recent advances in inflammation & allergy drug discovery · 2025
    Review
  9. Nails in older adults.Annals of medicine · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claire R StewartWeill Cornell Medical College, New York, New York, USA.
Leah AlguFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Rakhshan KamranMichael G. De Groote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Cameron F LeveilleDivision of Plastic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Khizar AbidFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Charlene RaeDepartment of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Shari R LipnerDepartment of Dermatology, Weill Cornell Medical College, New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At least 80% of patients with psoriasis will have nail involvement during their lifetimes. Understanding quality of life (QoL) impact of this condition and associated treatments is of utmost importance. Study objectives were to review the available literature describing patient-reported QoL outcomes in nail psoriasis and relationship with disease severity and treatment. A literature search was performed for English-language articles published prior to August 1, 2020. Articles were included in the review if primary data and validated patient-reported outcome measures assessing QoL were presented, and nail involvement was specifically examined. Fifteen studies were included in the final analysis. Patients with nail psoriasis had higher Psoriasis Area Severity Index and Dermatology Life Quality Index scores than those with psoriasis without nail involvement. The largest percent improvement in QoL score was associated with adalimumab. Studies investigating topicals, intralesionals, and systemic treatments were excluded since only biologic studies utilized validated patient-reported outcome measures. This review affirms that nail psoriasis is physically and emotionally distressing, warranting prompt treatment. Increased efforts are needed to address the impact of treatment on patient QoL using validated outcome measures that assess cosmetic, physical, and social problems.

Indexed as

Dermatology Life Quality IndexIndicatorsNail psoriasisNail Psoriasis Severity IndexPatient-reported outcome measuresPsoriasis Area Severity IndexQuality of lifeSystematic review

Identifiers

PMID33796553
PMCPMC7991285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.