Evidence map›Paper›PMID 33796512›Full record

ArticleOcular oncology and pathology2021

Intratumoral Heterogeneity in Uveal Melanoma.

Cristina Fonseca, Rita Pinto-Proença, Sabrina Bergeron, Luís Miguel Pires, Júlia Fernandes, Isabel Marques Carreira, Miguel N Burnier, Rui Proença

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Cristina FonsecaOcular Oncology Reference Center, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
Rita Pinto-ProençaMUHC - McGill University Ocular Pathology and Translational Research Laboratory, Montreal, Québec, Canada.
Sabrina BergeronMUHC - McGill University Ocular Pathology and Translational Research Laboratory, Montreal, Québec, Canada.
Luís Miguel PiresGenomics and Cytogenetics Laboratory, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Júlia FernandesOcular Oncology Reference Center, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
Isabel Marques CarreiraGenomics and Cytogenetics Laboratory, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Miguel N BurnierMUHC - McGill University Ocular Pathology and Translational Research Laboratory, Montreal, Québec, Canada.
Rui ProençaOcular Oncology Reference Center, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.
McGill University Health Centre · CAHospitais da Universidade de Coimbra · PTUniversity of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor biopsies in uveal melanoma (UM) serve mainly the purpose of prognostication and assessment of individual metastatic risk, but can be used for diagnosis in selected cases. The importance of precise information is paramount for selecting adequate surveillance protocols, patient counseling, and optimization of treatment strategies. However, intratumoral heterogeneity and sample representativity are major concerns and can interfere with the correct prediction of the patient's prognosis. We report a series of cases of UM with distinct morphologically identifiable areas, highlighting the differences in clinical behavior, as well as histopathological and genetic features.

Indexed as

BiopsyPrognosisTumor heterogeneityUveal melanoma

Identifiers

PMID33796512
PMCPMC7989676
OpenAlexW3080957315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.