Evidence map›Paper›PMID 33796503›Full record

ArticleFrontiers in chemistry2021

Zirconia Nanoparticles Induce HeLa Cell Death Through Mitochondrial Apoptosis and Autophagy Pathways Mediated by ROS.

Yinghui Shang, Qinghai Wang, Jian Li, Haiting Liu, Qiangqiang Zhao, Xueyuan Huang, Hang Dong, Wansong Chen, Rong Gui, Xinmin Nie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Investigation of Bio-Functional Properties of ZrOApplied biochemistry and biotechnology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yinghui ShangDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Qinghai WangDepartment of Cardiology, The Second Hospital of Shandong University, Jinan, China.
Jian LiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Haiting LiuDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Qiangqiang ZhaoDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Xueyuan HuangDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Hang DongDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Wansong ChenCollege of Chemistry and Chemical Engineering, Central South University, Changsha, China.
Rong GuiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Xinmin NieClinical Laboratory of the Third Xiangya Hospital, Central South University, Changsha, China.
Third Xiangya Hospital · CNCentral South University · CNSecond Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zirconia nanoparticles (ZrO

Indexed as

anticancerapoptosisautophagyreactive oxygen specieszirconia

Identifiers

PMID33796503
PMCPMC8007972
OpenAlexW3135910912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.