ArticleIEEE journal of translational engineering in health and medicine2021
Detecting Effect of Levodopa in Parkinson's Disease Patients Using Sustained Phonemes.
Article in IEEE journal of translational engineering in health and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 34 citations in OpenAlex.
- Speech Markers of Parkinson's Disease: Phonological Features and Acoustic Measures.Brain sciences · 2025Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Artificial Intelligence-Based Voice Assessment of Patients with Parkinson's Disease Off and On Treatment: Machine vs. Deep-Learning Comparison.Sensors (Basel, Switzerland) · 2023Article
- Ataxic speech disorders and Parkinson's disease diagnostics via stochastic embedding of empirical mode decomposition.PloS one · 2023Article
- Phonemes based detection of parkinson's disease for telehealth applications.Scientific reports · 2022Article
- Short-term effect of dopaminergic medication on speech in early-stage Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Voice Features of Sustained Phoneme as COVID-19 Biomarker.IEEE journal of translational engineering in health and medicine · 2022Article
- Evaluating the Effect of Parkinson's Disease on Jitter and Shimmer Speech Features.Advanced biomedical research · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is a multi-symptom neurodegenerative disease generally managed with medications, of which levodopa is the most effective. Determining the dosage of levodopa requires regular meetings where motor function can be observed. Speech impairment is an early symptom in PD and has been proposed for early detection and monitoring of the disease. However, findings from previous research on the effect of levodopa on speech have not shown a consistent picture.
methodThis study has investigated the effect of medication on PD patients for three sustained phonemes; /a/, /o/, and /m/, which were recorded from 24 PD patients during medication
resultsThe results show that medication has a significant effect on the change of time and amplitude perturbation (jitter and shimmer) and harmonics of /m/, which was the most sensitive individual phoneme to the levodopa response. /m/ and /o/ performed at a comparable level in discriminating PD-
conclusionStudies of phonation by computerized voice analysis in PD should employ recordings of multiple phonemes. Our findings are potentially relevant in research to identify early parkinsonian dysarthria, and to tele-monitoring of the levodopa response in patients with established PD.
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