ArticleBiomedical optics express2021
Gold nanoparticle enhanced detection of EGFR with a terahertz metamaterial biosensor.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 60 citations in OpenAlex.
- Immunomagnetic-MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor-Derived Exosomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Roadmap for light interaction with biophotonic surfaces and their diverse applications.Journal of biomedical optics · 2026Article
- Fano-resonant hybrid Metasurface for Carbon Dioxide sensing at telecommunication wavelengths.Scientific reports · 2026Article
- Design of a polarization-insensitive terahertz metamaterial biosensor for glioma tissue identification.Biomedical optics express · 2025Article
- The theory, technology, and application of terahertz metamaterial biosensors: A review.Fundamental research · 2025Review
- Review
- Terahertz Metamaterials for Biosensing Applications: A Review.Biosensors · 2023Review
- High specificity THz metamaterial-based biosensor for label-free transcription factor detection in melanoma diagnostics.Scientific reports · 2023Article
- Enhanced Near-Infrared Ultra-Narrow Absorber Based on a Dielectric Nano-Resonant Ring for Refractive Index Sensing.Sensors (Basel, Switzerland) · 2023Article
- Review
- Terahertz phase shift sensing and identification of a chiral amino acid based on a protein-modified metasurface through the isoelectric point and peptide bonding.Biomedical optics express · 2023Article
- Advances in terahertz technology for cancer detection applications.Optical and quantum electronics · 2023Review
- Metasurfaces for Sensing Applications: Gas, Bio and Chemical.Sensors (Basel, Switzerland) · 2022Review
- Monodisperse Gold Nanoparticles: A Review on Synthesis and Their Application in Modern Medicine.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidermal growth factor receptor (EGFR) plays an important role in the proliferation of various cancers, and the expression level of EGFR in tumor tissues can provide a basis for the diagnosis and prognosis. Improving the detection technology of EGFR to achieve high sensitivity and faster speed will benefit the diagnosis of many types of tumors. Trace biological samples can be sensitively measured with terahertz (THz) metamaterial devices. Here, a bow-tie array THz metamaterial biosensor is presented and modified with gold nanoparticles (GNPs) and EGFR antibodies for specific EGFR detection. The effect of the size of the GNP on the sensitivity enhancement was also analyzed. Enhanced sensing for EGFR was achieved with the assistance of GNPs and EGFR antibodies. Importantly, the metamaterial functionalized by GNPs and antibodies with a bigger GNP diameter achieves a greater resonance frequency shift. The proposed metamaterial biosensor can also realize tiny-volume EGFR solution detection. Our proposed technique can therefore sense EGFR sensitively with high speed, and can potentially be applied to achieve quick and accurate detection of EGFR related tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.