Evidence map›Paper›PMID 33796331›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

High prevalence of fatigue in contemporary patients with multiple sclerosis.

Line Broch, Cecilia Smith Simonsen, Heidi Øyen Flemmen, Pål Berg-Hansen, Åshild Skardhamar, Heidi Ormstad, Elisabeth Gulowsen Celius

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Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Extending the EQ-5D: the case for a complementary set of 4 psycho-social dimensions.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Line BrochDepartment of Neurology, Vestre Viken Hospital Trust, Drammen, Norway.ORCID https://orcid.org/0000-0002-9317-4901
Cecilia Smith SimonsenDepartment of Neurology, Vestre Viken Hospital Trust, Drammen, Norway.ORCID https://orcid.org/0000-0002-9408-7199
Heidi Øyen FlemmenDepartment of Neurology, Hospital Telemark HF, Skien, Norway.
Pål Berg-HansenDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Åshild SkardhamarDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Heidi OrmstadUniversity of South-Eastern Norway, Notodden, Norway.
Elisabeth Gulowsen CeliusDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0002-9127-6488

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe prevalence of multiple sclerosis (MS)-related fatigue may have changed due to new diagnostic criteria and new disease modifying drugs. We aimed to assess the prevalence of fatigue in a contemporary MS cohort, and to explore associations between fatigue and clinical and demographic factors.

methodsThis is a cross-sectional study of the MS population in three Norwegian counties. Fatigue was assessed with the Fatigue Scale for Motor and Cognitive Functions (FSMC). We also assessed self-reported anxiety, depression and daytime sleepiness.

resultsThe response rate was 64% (1599/2512). The mean age of the participants was 52 ± 13 years, median EDSS was 2.5 (IQR 1.5-3.0) and median disease duration from onset was 16 years (IQR 8-25). We found a prevalence of fatigue of 81%. Women had a higher prevalence of fatigue than men (83% vs 78%, p = 0.02). The prevalence increased with age (p < 0.001) and with increasing disease severity (p < 0.001), but in multivariate analyses, only sex and disease severity remained independent determinants of fatigue. Anxiety, depression, and daytime sleepiness were more prevalent in patients with fatigue than in those without fatigue (all p-values < 0.001).

conclusionThe prevalence of fatigue is high in contemporary patients with MS. Fatigue is associated with female sex and level of disability, as well as with anxiety, depression and excessive daytime sleepiness.

Indexed as

cohort studyfatigueMultiple sclerosisprevalence

Identifiers

PMID33796331
PMCPMC7985949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.