ArticleJournal of tissue engineering
Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Hyaluronan-Based Hybrid Systems as Growth Factor Carriers in the Treatment of Chronic Wounds.International journal of molecular sciences · 2025Review
- Exploring the wound healing potential of dietary nitrate in diabetic rat model.Frontiers in physiology · 2024Article
- Study of Salidroside and Its Inflammation Targeting Emulsion Gel for Wound Repair.Molecules (Basel, Switzerland) · 2023Article
- Construction of Smart Biomaterials for Promoting Diabetic Wound Healing.Molecules (Basel, Switzerland) · 2023Review
- Review
- A review of current advancements for wound healing: Biomaterial applications and medical devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Review
- HATMSC Secreted Factors in the Hydrogel as a Potential Treatment for Chronic Wounds-In Vitro Study.International journal of molecular sciences · 2021Article
- Dual-functional hybrid quaternized chitosan/Mg/alginate dressing with antibacterial and angiogenic potential for diabetic wound healing.Journal of orthopaedic translation · 2021Article
- Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies.Life (Basel, Switzerland) · 2021Review
- Large full-thickness wounded skin regeneration using 3D-printed elastic scaffold with minimal functional unit of skin.Journal of tissue engineeringArticle
- The rise of mechanical metamaterials: Auxetic constructs for skin wound healing.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with diabetes experience impaired growth factor production such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and they are reportedly involved in wound healing processes. Here, we report dual growth factor-loaded hyaluronate collagen dressing (Dual-HCD) matrix, using different ratios of the concentration of stabilized growth factors-stabilized-EGF (S-EGF) and stabilized-bFGF (S-bFGF). At first, the optimal concentration ratio of S-EGF to S-bFGF in the Dual-HCD matrix is determined to be 1:2 in type I diabetic mice. This Dual-HCD matrix does not cause cytotoxicity and can be used in vivo. The wound-healing effect of this matrix is confirmed in type II diabetic mice. Dual HCD enhances angiogenesis which promotes wound healing and thus, it shows a significantly greater synergistic effect than the HCD matrix loaded with a single growth factor. Overall, we conclude that the Dual-HCD matrix represents an effective therapeutic agent for impaired diabetic wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.