Evidence map›Paper›PMID 33796221›Full record

ArticleOncotarget2021

Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies.

Ryan R Kawalerski, Steven D Leach, Luisa F Escobar-Hoyos

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ryan R KawalerskiMedical Scientist Training Program, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Steven D LeachDepartments of Molecular and Systems Biology, Surgery, and Medicine, Dartmouth Geisel School of Medicine and Norris Cotton Cancer Center, Lebanon, NH 03766, USA.
Luisa F Escobar-HoyosDepartment of Therapeutic Radiology, Yale University, New Haven, CT 06513, USA.
Dartmouth College · USJohns Hopkins University · USStony Brook School · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Comprehensive genetic dissection of druggable KRAS targetsR01CA204228 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEACH, STEVEN D · 2016 to 2020
$1.9M
Altered mRNA splicing dependent on mutant p53 identifies novel therapeutic vulnerability in pancreatic cancerR00CA226342 · NCI · YALE UNIVERSITY · PI ESCOBAR HOYOS, LUISA · 2020 to 2022
$741k
NCI NIH HHS P30 CA023108NCI NIH HHS R00 CA226342NCI NIH HHS R01 CA204228
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer, has one of the highest case fatality rates of all known solid malignancies. Over the past decade, several landmark studies have established mutations in

Indexed as

KRASpancreatic cancerRNA splicingtargeted therapyTP53

Identifiers

PMID33796221
PMCPMC7984828
OpenAlexW3137173150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.