ArticlePolymer chemistry2020
Optimization of Ring-Opening Metathesis Polymerization (ROMP) under Physiologically Relevant Conditions.
Article in Polymer chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Hooked for Decay with Hydrophobic-Coated Magnetic Beads to Grapple and Disintegrate Nanoplastics.Angewandte Chemie (International ed. in English) · 2025Article
- Olefin Metathesis in Water: Speciation of a Leading Water-Soluble Catalyst Pinpoints Challenges and Opportunities for Chemical Biology.Journal of the American Chemical Society · 2025Article
- Anionic Olefin Metathesis Catalysts Enable Modification of Unprotected Biomolecules in Water.ACS catalysis · 2024Article
- Highly sensitive electrochemical quantification of carbendazim via synergistic enhancement of ring-opening metathesis polymerization and polyethyleneimine modified graphene oxide.Mikrochimica acta · 2024Article
- Water-soluble polyphosphonate-based bottlebrush copolymersChemical science · 2023Article
- Probing Catalyst Degradation in Metathesis of Internal Olefins: Expanding Access to Amine-Tagged ROMP Polymers.ACS catalysis · 2023Article
- Water-Accelerated Decomposition of Olefin Metathesis Catalysts.ACS catalysis · 2023Article
- Polynorbornene-based bioconjugates by aqueous grafting-from ring-opening metathesis polymerization reduce protein immunogenicity.Cell reports. Physical science · 2022Article
- Mechanochemical ring-opening metathesis polymerization: development, scope, and mechano-exclusive polymer synthesis.Chemical science · 2022Article
- The Janus face of high trans-effect carbenes in olefin metathesis: gateway to both productivity and decomposition.Chemical science · 2022Article
- Bimolecular Coupling in Olefin Metathesis: Correlating Structure and Decomposition for Leading and Emerging Ruthenium-Carbene Catalysts.Journal of the American Chemical Society · 2021Article
- Routes to High-Performing Ruthenium-Iodide Catalysts for Olefin Metathesis: Ligand Lability Is Key to Efficient Halide Exchange.Organometallics · 2021Article
- The Impact of Water on Ru-Catalyzed Olefin Metathesis: Potent Deactivating Effects Even at Low Water Concentrations.ACS catalysis · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ring opening metathesis polymerization (ROMP) is widely considered an excellent living polymerization technique that proceeds rapidly under ambient conditions and is highly functional group tolerant when performed in organic solvents. However, achieving the same level of success in aqueous media has proved to be challenging, often requiring an organic co-solvent or a very low pH to obtain fast initiation and high monomer conversion. The ability to efficiently conduct ROMP under neutral pH aqueous conditions would mark an important step towards utilizing aqueous ROMP with acid-sensitive functional groups or within a biological setting. Herein we describe our efforts to optimize ROMP in an aqueous environment under neutral pH conditions. Specifically, we found that the presence of excess chloride in solution as well as relatively small changes in pH near physiological conditions have a profound effect on molecular weight control, polymerization rate and overall monomer conversion. Additionally, we have applied our optimized conditions to polymerize a broad scope of water-soluble monomers and used this methodology to produce nanostructures via ring opening metathesis polymerization induced self-assembly (ROMPISA) under neutral pH aqueous conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.