Evidence map›Paper›PMID 33796141›Full record

ReviewTherapeutic advances in neurological disorders2021

Paraneoplastic neurological syndromes: clinical presentations and management.

Michelle F Devine, Naga Kothapalli, Mahmoud Elkhooly, Divyanshu Dubey

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in neurological disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Michelle F DevineDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Naga KothapalliDepartment of Neurology, University of Pittsburgh Medical Center, Pittsburg, PA, USA.
Mahmoud ElkhoolyDepartment of Neuropsychiatry, Minia University, Minia, Egypt.
Divyanshu DubeyDepartment of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905-0002, USA.ORCID https://orcid.org/0000-0001-6865-9045
Mayo Clinic · USMayo Clinic in Arizona · USMinia University · EGUniversity of Pittsburgh Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We provide an overview of the varied presentations of paraneoplastic neurological syndromes. We also review the onconeural antibodies and their particular oncological and neurological associations. Recognition of these syndromes and their oncological associations is crucial, as early diagnosis and management has been associated with better patient outcomes. Specific management strategies and prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information can help tailor treatment approaches. We provide an outline of the diagnostic evaluation and treatment of various paraneoplastic neurological disorders, presenting with central and/or peripheral nervous system involvement. We briefly discuss neurologic immune checkpoint inhibitor-related adverse events, which can occasionally present with paraneoplastic neurological syndrome phenotypes.

Indexed as

immune checkpoint inhibitoronconeural antibodiesparaneoplastic neurological disorderParaneoplastic neurological syndrome

Identifiers

PMID33796141
PMCPMC7970694
OpenAlexW3126679399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.