Evidence map›Paper›PMID 33796119›Full record

ArticleFrontiers in immunology2021

Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques.

Nuria Pedreño-Lopez, Brandon C Rosen, Walter J Flores, Matthew J Gorman, Thomas B Voigt, Michael J Ricciardi, Kristin Crosno, Kim L Weisgrau, Christopher L Parks, Jeffrey D Lifson and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Nuria Pedreño-LopezDepartment of Pathology, George Washington University, Washington, DC, United States.
Brandon C RosenDepartment of Pathology, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.
Walter J FloresNonhuman Primate Reagent Resource, MassBiologics of the University of Massachusetts Medical School, Boston, MA, United States.
Matthew J GormanRagon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard University, Cambridge, MA, United States.
Thomas B VoigtDepartment of Pathology, George Washington University, Washington, DC, United States.
Michael J RicciardiDepartment of Pathology, George Washington University, Washington, DC, United States.
Kristin CrosnoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Kim L WeisgrauWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Christopher L ParksInternational AIDS Vaccine Initiative, AIDS Vaccine Design and Development Laboratory, Brooklyn, NY, United States.
Jeffrey D LifsonAIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Galit AlterRagon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard University, Cambridge, MA, United States.
Eva G RakaszWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States.
Diogo M MagnaniNonhuman Primate Reagent Resource, MassBiologics of the University of Massachusetts Medical School, Boston, MA, United States.
Mauricio A MartinsDepartment of Immunology and Microbiology, Scripps Research, Jupiter, FL, United States.
David I WatkinsDepartment of Pathology, George Washington University, Washington, DC, United States.
George Washington University · USUniversity of Wisconsin–Madison · USRagon Institute of MGH, MIT and Harvard · USUniversity of Massachusetts Chan Medical School · USInternational AIDS Vaccine Initiative · USLeidos (United States) · USScripps Research Institute · USUniversity of Miami · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
The Functional Significance of Cytotoxic T Lymphocyte EscapeR01AI052056 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 2003 to 2024
$8.3M
Retargeting cytotoxic T lymphocytes in HIV/SIV infection to kill infected cellsF30AI147881 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ROSEN, BRANDON C · 2019 to 2022
$199k
CCR NIH HHS HHSN261200800001CNCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261200800001ENIAID NIH HHS F30 AI147881NIAID NIH HHS R01 AI052056NIAID NIH HHS U24 AI126683NIH HHS P51 OD011106
6 · The paper itself

Abstract

The antiviral properties of broadly neutralizing antibodies against HIV are well-documented but no vaccine is currently able to elicit protective titers of these responses in primates. While current vaccine modalities can readily induce non-neutralizing antibodies against simian immunodeficiency virus (SIV) and HIV, the ability of these responses to restrict lentivirus transmission and replication remains controversial. Here, we investigated the antiviral properties of non-neutralizing antibodies in a group of Indian rhesus macaques (RMs) that were vaccinated with

Indexed as

AnimalsAntibodies, ViralBiomarkersGenotypeHistocompatibility Antigens Class IHost-Pathogen InteractionsImmunoglobulin GMacaca mulattaReceptors, FcSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadViremiaAntibodies, ViralBiomarkersFc receptor, neonatalHistocompatibility Antigens Class IImmunoglobulin GReceptors, Fcadoptive transferantibody depletionanti-FcRn Abimmunoadsorptionnon-neutralizing antibodiesrhesus macaques (Macaca mulatta)SIV

Identifiers

PMID33796119
PMCPMC8008062
OpenAlexW3139053610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.