Evidence map›Paper›PMID 33796081›Full record

ArticleFrontiers in endocrinology2021

Growing Up Under Constant Light: A Challenge to the Endocrine Function of the Leydig Cells.

Dijana Z Marinkovic, Marija L J Medar, Alisa P Becin, Silvana A Andric, Tatjana S Kostic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. The impact of probiotics on testosterone synthesis in the TM3 cell line.Clinical and experimental reproductive medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dijana Z MarinkovicLaboratory for Chronobiology and Aging, Laboratory for Reproductive Endocrinology and Signaling, Department for Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Marija L J MedarLaboratory for Chronobiology and Aging, Laboratory for Reproductive Endocrinology and Signaling, Department for Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Alisa P BecinLaboratory for Chronobiology and Aging, Laboratory for Reproductive Endocrinology and Signaling, Department for Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Silvana A AndricLaboratory for Chronobiology and Aging, Laboratory for Reproductive Endocrinology and Signaling, Department for Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Tatjana S KosticLaboratory for Chronobiology and Aging, Laboratory for Reproductive Endocrinology and Signaling, Department for Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
University of Novi Sad · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The factors influencing Leydig cell maturity and the acquisition of functional capacity are incompletely defined. Here we analyzed the constant light (LL) influence on Leydig cells' endocrine function during reproductive maturation. Rats were exposed to LL from P21 to P90. Data were collected at juvenile (P35), peri/pubertal (P42, P49), and adult (P90) stages of life. The results proved the effect of LL on rats' physiology by changing of bimodal voluntary activity pattern into free-running. Additionally, the peripheral clock in Leydig cells changed in LL condition, indicating disturbed rhythm: the positive element (

Indexed as

LightAdenosine TriphosphateAndrogensAnimalsBody WeightCell DifferentiationCorticosteroneDNA, MitochondrialEndocrine SystemGTP PhosphohydrolasesLeydig CellsLuteinizing HormoneMaleMembrane Potential, MitochondrialMitochondriaMitochondrial ProteinsAdenosine TriphosphateAndrogensCorticosteroneDNA, MitochondrialGTP PhosphohydrolasesLuteinizing HormoneMfn2 protein, ratMitochondrial ProteinsOpa1 protein, ratProtein KinasesPTEN-Induced Putative KinaseSteroidsTestosteroneclockconstant lightLeydig cellmitochondriapubertysteroidogenesis

Identifiers

PMID33796081
PMCPMC8008111
OpenAlexW3136414760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.