ArticleFrontiers in neurology2021
The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample.
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Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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36citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Cognitive Impairment and Dementia-Related Diagnoses in Chronic Traumatic Encephalopathy: A Systematic Review and Meta-Analysis.Neurology · 2025Pooled it
- The Role of GFAP in Post-Mortem Analysis of Traumatic Brain Injury: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Chronic traumatic encephalopathy in a neuropathologically confirmed Creutzfeldt-Jakob disease cohort.Brain pathology (Zurich, Switzerland) · 2026Article
- USP18/DDX5 axis ameliorates mitochondrial morphofunctional damage via OPA1 to inhibit neuronal apoptosis after traumatic brain injury.Redox biology · 2026Article
- Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study.Journal of Alzheimer's disease : JAD · 2026Article
- Clinicopathological study of chronic traumatic encephalopathy pathology in a population-based cohort.Journal of neuropathology and experimental neurology · 2026Article
- Chronic traumatic encephalopathy neuropathologic change is associated with highest stage limbic-predominant age-related TDP-43 encephalopathy.Journal of neuropathology and experimental neurology · 2026Article
- On media and messaging: fighting fear with facts as the science of chronic traumatic encephalopathy evolves.British journal of sports medicine · 2026Article
- Chronic traumatic encephalopathy neuropathologic change in the Late Effects of Traumatic Brain Injury project: Findings in a community autopsy cohort.Journal of neuropathology and experimental neurology · 2025Article
- Chronic traumatic encephalopathy: State-of-the-science update and narrative review.The Clinical neuropsychologist · 2025Review
- Clinical and Neuropsychological Profiles in People With Chronic Traumatic Encephalopathy Neuropathologic Change: Matched Case-Series Study.Neurology · 2025Article
- Traumatic brain injury, changes in plasma amyloid, tau, and neurodegenerative biomarkers, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Traumatic Brain Injury and Dementia: Mechanisms, Risk Stratification, and Clinical Management.Journal of clinical neurology (Seoul, Korea) · 2025Review
- Traumatic Encephalopathy Syndrome in the Late Effects of Traumatic Brain Injury (LETBI) Study Cohort.Neurology open access · 2025Article
- The prevalence of chronic traumatic encephalopathy in a historical epilepsy post-mortem collection.Brain pathology (Zurich, Switzerland) · 2025Article
- Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE).Sports medicine (Auckland, N.Z.) · 2025Review
- Neuroinflammation and neurodegeneration following traumatic brain injuries.Anatomical science international · 2025Review
- Mechanisms Underlying Hazardous Alcohol Use After Mild Traumatic Brain Injury.Alcohol research : current reviews · 2025Review
- Ante-Mortem Clinical Characterization with Post-Mortem Family Interview and Medical Record Abstraction in a Traumatic Brain Injury Brain Donor Program.Neurotrauma reports · 2025Article
- GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.Nature genetics · 2024Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 1 country.
Nadia PostupnaDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Shannon E RoseDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Laura E GibbonsDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Natalie M ColemanDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Leanne L HellsternDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Kayla RitchieDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Angela M WilsonDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Eiron CudabackDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Xianwu LiDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Erica J MeliefDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Allison E BellerDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Jeremy A MillerAllen Institute for Brain Science, Seattle, WA, United States.
Amber L NolanDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Desiree A MarshallDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
Rod WalkerKaiser Permanente Washington Health Research Institute, Seattle, WA, United States.
Thomas J MontineDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA, United States.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA, United States.
Paul K CraneDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, United States.
Richard G EllenbogenDepartment of Neurological Surgery, University of Washington School of Medicine, Seattle, WA, United States.
Edward S LeinAllen Institute for Brain Science, Seattle, WA, United States.
Kristen Dams-O'ConnorDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.
University of Washington · USKaiser Permanente Washington Health Research Institute · USAllen Institute · USIcahn School of Medicine at Mount Sinai · USNeurological Surgery · USStanford University · US
Funding
Topographic, cell type and molecular pathway characterization ofAlzheimer's disease using single cell transcriptomics and epigenomicsU19AG060909 · NIA · ALLEN INSTITUTE · PI Michael Hawrylycz · 2020 to 2026
$83.6MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2MFurthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV · 2020 to 2026
$29.0MThe Late Effects of TBI (LETBI) Study: Injury Patterns and Biological Markers of Post-Traumatic NeurodegenerationRF1NS115268 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kristen Dams-O'Connor · 2019 to 2026
$10.3MData Coordinating CoreU54NS115322 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2019 to 2023
$9.2MNeuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1MLeveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)R01AG061028 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN, MEZ, JESSE BENJAMIN · 2019 to 2023
$5.9MCortical Somatostatin Interneuron Dysfunction after Trauma: Role in Cognitive FlexibilityK08NS114170 · NINDS · UNIVERSITY OF WASHINGTON · PI NOLAN, AMBER L · 2019 to 2023
$1.0MNIA NIH HHS P30 AG066509NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG061028NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG060909NINDS NIH HHS K08 NS114170NINDS NIH HHS RF1 NS115268NINDS NIH HHS U01 NS086625NINDS NIH HHS U54 NS115322
Abstract
The late neuropathological effects of traumatic brain injury have yet to be fully elucidated, particularly with respect to community-based cohorts. To contribute to this critical gap in knowledge, we designed a multimodal neuropathological study, integrating traditional and quantitative approaches to detect pathologic changes in 532 consecutive brain autopsies from participants in the Adult Changes in Thought (ACT) study. Diagnostic evaluation including assessment for chronic traumatic encephalopathy (CTE) and quantitative immunoassay-based methods were deployed to examine levels of pathological (hyperphosphorylated) tau (pTau) and amyloid (A) β in brains from ACT participants with (
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Adult Changes in Thought studyamyloid–betachronic traumatic encephalopathyhistelidehyperphosphorylated tauimmunohistochemistrytraumatic brain injury
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