Evidence map›Paper›PMID 33795956›Full record

ReviewNoro psikiyatri arsivi2021

Central Role of T Follicular Helper Cells in Myasthenia Gravis.

Na Wu, Erdem Tüzün, Yi Cheng, Li Yan, Yajun Wu, Jie Rao, Hui Huang, Siyu Li, Ling Shi, Xiaorong Wu

Open access · greenAbstract readReview
In one paragraph

Review in Noro psikiyatri arsivi, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Na WuDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Erdem TüzünDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medical Research, İstanbul University, İstanbul, Turkey.
Yi ChengDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Li YanDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Yajun WuDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Jie RaoDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Hui HuangDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Siyu LiDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Ling ShiDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Xiaorong WuDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Nanchang University · CNFirst Affiliated Hospital of Nanchang University · CNIstanbul University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia gravis (gMG) is a critical autoimmune disease, which has a serious impact on the life and survival of patients. Ocular Myasthenia Gravis (oMG) is often the initial manifestation of MG and has the potential to progress to gMG. However, to date no distinct mechanism has been found to clarify the pathogenesis of conversion from oMG to gMG. Recent studies have shown that the development and clinical progression of MG is closely associated with the abnormal function of follicular helper T (Tfh) cells. Thus, this article reviews the recently achieved research progress on the involvement of Tfh cells in MG immunopathogenesis and focuses on the role of Tfh cells and related-factors (IL-21, CXCL13, CXCR5, bcl-6 etc.) in germinal center formation and antibody production in MG immune response.

Indexed as

follicular helper T cellsGeneralized myasthenia gravisgerminal centersocular myasthenia gravispathogenesis

Identifiers

PMID33795956
PMCPMC7980705
OpenAlexW3033289267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.