Evidence map›Paper›PMID 33795874›Full record

ArticleNature cell biology2021

m

Pingyu Liu, Fuming Li, Jianhuang Lin, Takeshi Fukumoto, Timothy Nacarelli, Xue Hao, Andrew V Kossenkov, M Celeste Simon, Rugang Zhang

Open access · greenAbstract read
In one paragraph

Article in Nature cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 185 citations in OpenAlex.

  1. Article
  2. Article
  3. mExperimental and therapeutic medicine · 2026
    Review
  4. mNature metabolism · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Chromatin accessibility regulates age-dependent nuclear mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pingyu LiuImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Fuming LiAbramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2603-1548
Jianhuang LinImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0035-0938
Takeshi FukumotoImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Timothy NacarelliImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Xue HaoImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
Andrew V KossenkovImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA.
M Celeste SimonAbramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9106-447X
Rugang ZhangImmunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA, USA. rzhang@wistar.org.ORCID http://orcid.org/0000-0002-7255-2360
The Wistar Institute · USCancer Research Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
STRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI GARCIA, BENJAMIN A · 2008 to 2022
$28.3M
SPORE in Ovarian CancerP50CA228991 · NCI · JOHNS HOPKINS UNIVERSITY · PI Tian-Li Wang · 2018 to 2026
$20.5M
Metabolic Tumor Suppressors in Renal Cancer: Unprecedented Roles in Disease ProgressionR35CA220483 · NCI · UNIVERSITY OF PENNSYLVANIA · PI M. CELESTE SIMON · 2017 to 2026
$9.4M
Mechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancerR01CA202919 · NCI · WISTAR INSTITUTE · PI Xi Chen, Rugang Zhang · 2016 to 2026
$4.1M
Role of BRCA1 Pathway in Regulating Oncogene-Induced SenescenceR01CA160331 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$4.0M
Targeting EZH2 in CARM1-expressing epithelial ovarian cancerR01CA163377 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$3.7M
Regulation of tumor recurrence by stress activated neutrophilsR01CA243142 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2020 to 2025
$2.8M
Synthetic lethality based combination approaches to ARID1A mutation in ovarian cancerR01CA239128 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2019 to 2024
$2.5M
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6M
NCI NIH HHS P30 CA010815NCI NIH HHS P50 CA228991NCI NIH HHS R01 CA160331NCI NIH HHS R01 CA163377NCI NIH HHS R01 CA202919NCI NIH HHS R01 CA239128NCI NIH HHS R01 CA243142NCI NIH HHS R35 CA220483NCI NIH HHS R50 CA211199NIA NIH HHS P01 AG031862
6 · The paper itself

Abstract

Methyltransferase-like 3 (METTL3) and 14 (METTL14) are core subunits of the methyltransferase complex that catalyses messenger RNA N

Indexed as

AdenosineAgingAnimalsCellular SenescenceDNA MethylationGenomeMethyltransferasesMiceNF-kappa BRNA, MessengerAdenosineMethyltransferasesMettl14 protein, mouseMettl3 protein, mouseNF-kappa BN-methyladenosineRNA, Messenger

Identifiers

PMID33795874
PMCPMC8035315
OpenAlexW3139716940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.