ArticleNature chemistry2021
Selective discrimination and classification of G-quadruplex structures with a host-guest sensing array.
Article in Nature chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 96 citations in OpenAlex.
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- Fluorescence turn-on sensing and imaging of kinetin using tetralactam macrocycle-based supramolecular probe.Mikrochimica acta · 2025Article
- A Column Chromatography-Free Protocol for the Synthesis of Water-Soluble Cavitands.The Journal of organic chemistry · 2025Article
- Optical Chemosensors Synthesis and Appplication for Trace Level Metal Ions Detection in Aqueous Media: A Review.Journal of fluorescence · 2025Review
- Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays.BBA advances · 2025Article
- The Versatile Applications of Calix[4]resorcinarene-Based Cavitands.Molecules (Basel, Switzerland) · 2024Review
- Precise AIE-Based Ternary Co-Assembly for Saccharide Recognition and Classification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mixed host co-assembled systems for broad-scope analyte sensing.Chemical science · 2024Article
- DNA Framework-Engineered Assembly of Cyanine Dyes for Structural Identification of Nucleic Acids.JACS Au · 2024Article
- "Gear-driven"-type chirality transfer of tetraphenylethene-based supramolecular organic frameworks for peptides in water.Chemical science · 2024Article
- Selective recognition and discrimination of single isomeric changes in peptide strands with a host : guest sensing array.Chemical science · 2024Article
- Self-Assembled DNA Machine and Selective Complexation Recognition Enable Rapid Homogeneous Portable Quantification of Lung Cancer CTCs.Research (Washington, D.C.) · 2024Article
- Promoter R-Loops Recruit U2AF1 to Modulate Its Phase Separation and RNA Splicing.Journal of the American Chemical Society · 2023Article
- Multi-analyte sensing strategies towards wearable and intelligent devices.Chemical science · 2022Review
- Using ultraviolet absorption spectroscopy to study nanoswitches based on non-canonical DNA structures.Biochemistry and biophysics reports · 2022Article
- Further Dimensions for Sensing in Biofluids: Distinguishing Bioorganic Analytes by the Salt-Induced Adaptation of a Cucurbit[7]uril-Based Chemosensor.Journal of the American Chemical Society · 2022Article
- A facile way to construct sensor array library via supramolecular chemistry for discriminating complex systems.Nature communications · 2022Article
- Development of RNA G-quadruplex (rG4)-targeting L-RNA aptamers by rG4-SELEX.Nature protocols · 2022Review
- Nanomaterial-Based Label-Free Electrochemical Aptasensors for the Detection of Thrombin.Biosensors · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secondary structures of nucleic acids have an important influence on their cellular functions but can be difficult to identify and classify quickly. Here, we show that an arrayed suite of synthetic hosts and dyes is capable of fluorescence detection of oligonucleotide secondary structures. Multivariate analysis of different fluorescence enhancements-generated using cationic dyes that show affinity for both DNA G-quadruplexes and the synthetic hosts-enables discrimination between G-quadruplex structures of identical length and highly similar topological types. Different G-quadruplexes that display the same folding topology can also be easily differentiated by the number of G-quartets and sequence differences at the 3' or 5' ends. The array is capable of both differentiation and classification of the G-quadruplex structures at the same time. This simple non-invasive sensing method does not require the discovery and synthesis of specific G-quadruplex binding ligands, but employs a simple multicomponent approach to ensure wide applicability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.