Evidence map›Paper›PMID 33795683›Full record

ArticleNature communications2021

A KRAS-responsive long non-coding RNA controls microRNA processing.

Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brullé-Soumaré, Stefano Cairo, Tiziana Monteverde and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Chemically modified non-coding RNAs in cancer.Expert reviews in molecular medicine · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Targeting ST8SIA6-AS1 counteracts KRASExperimental hematology & oncology · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Lei ShiTranscriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.ORCID 0000-0003-4027-2396
Peter MageeTranscriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Matteo FassanDepartment of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.ORCID 0000-0001-6515-5482
Sudhakar SahooComputational Biology Support, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Hui Sun LeongComputational Biology Support, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Dave LeeComputational Biology Support, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Robert SellersComputational Biology Support, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Laura Brullé-SoumaréXentech, 4 rue Pierre Fontaine, Evry, France.ORCID 0000-0003-3371-2496
Stefano CairoXentech, 4 rue Pierre Fontaine, Evry, France.ORCID 0000-0002-4725-5970
Tiziana MonteverdeTranscriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Stefano VoliniaDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Duncan D SmithBiological Mass Spectrometry Facility, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Gianpiero Di LevaSchool of Pharmacy and Bioengineering, Keele University, Stock-on-Trent, UK.
Francesca GaluppiniDepartment of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Athanasios R PaliourasTranscriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Kang ZengImaging & Cytometry Facility, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.
Raymond O'KeefeDivision of Evolution & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID 0000-0001-8764-1289
Michela GarofaloTranscriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK. michelagarofalo1@gmail.com.ORCID 0000-0002-1741-0415
University of Manchester · GBCancer Research UK · GBUniversity of Padua · ITKeele University · GBUniversity of Ferrara · IT

Funding

Cancer Research UK C5759/A20465Cancer Research UK C5759/A20971
6 · The paper itself

Abstract

Wild-type KRAS (KRAS

Indexed as

Gene Expression Regulation, NeoplasticA549 CellsAnimalsCarcinoma, Non-Small-Cell LungCell Line, TumorFemaleGene Expression ProfilingGene OntologyHumansKaplan-Meier EstimateLung NeoplasmsMiceMice, Inbred NODMice, KnockoutMice, SCIDMicroRNAsKRAS protein, humanMicroRNAsNPM1 protein, humanNpm1 protein, mouseNucleophosminProto-Oncogene Proteins p21(ras)RNA, Long Noncoding

Identifiers

PMID33795683
PMCPMC8016872
OpenAlexW3144478612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.