Evidence map›Paper›PMID 33795616›Full record

ArticleEar and hearing

The Sensitivity of the Electrically Stimulated Auditory Nerve to Amplitude Modulation Cues Declines With Advanced Age.

William J Riggs, Chloe Vaughan, Jeffrey Skidmore, Sara Conroy, Angela Pellittieri, Brittney L Carter, Curtis J Stegman, Shuman He

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ear and hearing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

William J RiggsDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Chloe VaughanDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Jeffrey SkidmoreDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Sara ConroyCenter for Biostatistics, Department of Bioinformatics, The Ohio State University, Columbus, Ohio, USA.
Angela PellittieriHead and Neck Institute, The Cleveland Clinic, Cleveland, Ohio, USA.
Brittney L CarterDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Curtis J StegmanDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Shuman HeDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
The Ohio State University · USCleveland Clinic · USNationwide Children's Hospital · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
NEURAL ENCODING AND AUDITORY PERCEPTION IN COCHLEAR IMPLANT USERSR01DC016038 · NIDCD · OHIO STATE UNIVERSITY · PI HE, SHUMAN · 2017 to 2021
$2.3M
NCATS NIH HHS UL1 TR002733NIDCD NIH HHS R01 DC016038
6 · The paper itself

Abstract

objectivesThis study aimed to investigate effects of aging and duration of deafness on sensitivity of the auditory nerve (AN) to amplitude modulation (AM) cues delivered using trains of biphasic pulses in adult cochlear implant (CI) users.

designThere were 21 postlingually deaf adult CI users who participated in this study. All study participants used a Cochlear Nucleus device with a full electrode array insertion in the test ear. The stimulus was a 200-ms pulse train with a pulse rate of 2000 pulses per second. This carrier pulse train was sinusodially AM at four modulation rates (20, 40, 100, 200 Hz). The peak amplitude of the modulated pulse train was the maximum comfortable level (i.e., C level) measured for the carrier pulse train. The electrically evoked compound action potential (eCAP) to each of the 20 pulses selected over the last two AM cycles were measured. In addition, eCAPs to single pulses were measured with the probe levels corresponding to the levels of 20 selected pulses from each AM pulse train. There were seven electrodes across the array evaluated in 16 subjects (i.e., electrodes 3 or 4, 6, 9, 12, 15, 18, and 21). For the remaining five subjects, 4 to 5 electrodes were tested due to impedance issues or time constraints. The modulated response amplitude ratio (MRAR) was calculated as the ratio of the difference in the maximum and the minimum eCAP amplitude measured for the AM pulse train to that measured for the single pulse, and served as the dependent variable. Age at time of testing and duration of deafness measured/defined using three criteria served as the independent variables. Linear Mixed Models were used to assess the effects of age at testing and duration of deafness on the MRAR.

resultsAge at testing had a strong, negative effect on the MRAR. For each subject, the duration of deafness varied substantially depending on how it was defined/measured, which demonstrates the difficulty of accurately measuring the duration of deafness in adult CI users. There was no clear or reliable trend showing a relationship between the MRAR measured at any AM rate and duration of deafness defined by any criteria. After controlling for the effect of age at testing, MRARs measured at 200 Hz and basal electrode locations (i.e., electrodes 3 and 6) were larger than those measured at any other AM rate and apical electrode locations (i.e., electrodes 18 and 21).

conclusionsThe AN sensitivity to AM cues implemented in the pulse-train stimulation significantly declines with advanced age. Accurately measuring duration of deafness in adult CI users is challenging, which, at least partially, might have accounted for the inconclusive findings in the relationship between the duration of deafness and the AN sensitivity to AM cues in this study.

Indexed as

Cochlear ImplantationCochlear ImplantsDeafnessAdultCochlear NerveCuesElectric StimulationEvoked Potentials, AuditoryHumans

Identifiers

PMID33795616
PMCPMC8387330
OpenAlexW3142897053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.