Evidence map›Paper›PMID 33795482›Full record

ArticlePediatrics2021

Metric Development for the Multicenter Improving Pediatric Sepsis Outcomes (IPSO) Collaborative.

Raina Paul, Matthew Niedner, Richard Brilli, Charles Macias, Ruth Riggs, Frances Balamuth, Holly Depinet, Gitte Larsen, Charlie Huskins, Halden Scott and 10 more

Abstract read
In one paragraph

Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Raina PaulDivision of Emergency Medicine, Advocate Children's Hospital, Park Ridge, Illinois; raina159@gmail.com.
Matthew NiednerDivision of Pediatric Critical Care Medicine, Department of Pediatrics, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Richard BrilliDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
Charles MaciasDivision of Pediatric Emergency Medicine, Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio.
Ruth RiggsChildren's Hospital Association, Lenexa, Kansas.
Frances BalamuthDepartment of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Holly DepinetDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Gitte LarsenPediatric Critical Care, Department of Pediatrics, Primary Children's Hospital, Salt Lake City, Utah.
Charlie HuskinsDivision of Pediatric Infectious Diseases, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Halden ScottDepartment of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado.
Gloria LucasiewiczChildren's Hospital Association, Lenexa, Kansas.
Melissa SchafferDepartment of Pediatrics, Upstate Medical University, Syracuse, New York.
Heidi Gruhler DeSouzaChildren's Hospital Association, Lenexa, Kansas.
Pete SilverDepartment of Pediatrics, Zucker School of Medicine at Hofstra, Cohen Children's Medical Center, East Garden City, New York.
Troy RichardsonChildren's Hospital Association, Lenexa, Kansas.
Leslie HueschenSection of Pediatric Emergency Medicine, Department of Pediatrics, University of Missouri-Kansas City and Children's Mercy Hospital, Kansas City, Missouri.
Deborah CampbellKentucky Hospital Association, Louisville, Kentucky; and.
Beth WathenDepartment of Pediatrics, School of Medicine, University of Colorado, Aurora, Colorado.
Jeffery J AulettaDivisions of Hematology, Oncology, and Blood and Marrow Transplant and Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital and College of Medicine, The Ohio State University, Columbus, Ohio.
IPSO COLLABORATIVE INVESTIGATORS

Funding

Pediatric septic acute kidney injury: personalizing antibiotic dosing through understanding acute kidney injury risk factors and biomarker profilesK23DK119463 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI FITZGERALD, JULIE C. HOLLOWS · 2020 to 2024
$810k
Enhancing Quality in Pediatrics Sepsis with Shock Prediction and Early Electronic Decision Support (EQUIP with SPEED)K08HS025696 · AHRQ · UNIVERSITY OF COLORADO DENVER · PI SCOTT, HALDEN F · 2018 to 2022
$742k
AHRQ HHS K08 HS025696NIDDK NIH HHS K23 DK119463
6 · The paper itself

Abstract

backgroundA 56 US hospital collaborative, Improving Pediatric Sepsis Outcomes, has developed variables, metrics and a data analysis plan to track quality improvement (QI)-based patient outcomes over time. Improving Pediatric Sepsis Outcomes expands on previous pediatric sepsis QI efforts by improving electronic data capture and uniformity across sites.

methodsAn expert panel developed metrics and corresponding variables to assess improvements across the care delivery spectrum, including the emergency department, acute care units, hematology and oncology, and the ICU. Outcome, process, and balancing measures were represented. Variables and statistical process control charts were mapped to each metric, elucidating progress over time and informing plan-do-study-act cycles. Electronic health record (EHR) abstraction feasibility was prioritized. Time 0 was defined as time of earliest sepsis recognition (determined electronically), or as a clinically derived time 0 (manually abstracted), identifying earliest physiologic onset of sepsis.

resultsTwenty-four evidence-based metrics reflected timely and appropriate interventions for a uniformly defined sepsis cohort. Metrics mapped to statistical process control charts with 44 final variables; 40 could be abstracted automatically from multiple EHRs. Variables, including high-risk conditions and bedside huddle time, were challenging to abstract (reported in <80% of encounters). Size or type of hospital, method of data abstraction, and previous QI collaboration participation did not influence hospitals' abilities to contribute data. To date, 90% of data have been submitted, representing 200 007 sepsis episodes.

conclusionsA comprehensive data dictionary was developed for the largest pediatric sepsis QI collaborative, optimizing automation and ensuring sustainable reporting. These approaches can be used in other large-scale sepsis QI projects in which researchers seek to leverage EHR data abstraction.

Indexed as

Data CollectionPatient Outcome AssessmentQuality ImprovementSepsisChildHumansPediatricsUnited States

Identifiers

PMID33795482
PMCPMC8131032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.