Trial reportThe European respiratory journal2021
Continuous positive airway pressure improves blood pressure and serum cardiovascular biomarkers in obstructive sleep apnoea and hypertension.
Trial report in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Benefits of continuous positive airway pressure on blood pressure in patients with hypertension and obstructive sleep apnea: a meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Pooled it
- Effect of positive airway pressure on cardiac troponins in patients with sleep-disordered breathing: A meta-analysis.Clinical cardiology · 2022Pooled it
- Daily Exposure to Mild Intermittent Hypoxia Reduces Blood Pressure in Male Patients with Obstructive Sleep Apnea and Hypertension.American journal of respiratory and critical care medicine · 2022Trial
- Effects of Continuous Positive Airway Pressure for Hypertension in Patients with Obstructive Sleep Apnoea: A Structured Narrative Review of Randomised Controlled Trials.Journal of clinical medicine · 2026Review
- Feasibility and impact of personalized therapy for obstructive sleep apnea in patients with acute coronary syndrome: a pilot randomized controlled trial.Pilot and feasibility studies · 2026Article
- The effect of continuous positive airway pressure on nocturnal blood pressure among obstructive sleep apnea-hypopnea syndrome patients.Sleep & breathing = Schlaf & Atmung · 2025Article
- The Correlation Between Sleep and Coronary Heart Disease: A Review.Reviews in cardiovascular medicine · 2025Review
- Cardiovascular effects of obstructive sleep apnoea and effects of continuous positive airway pressure therapy: evidence from different study models.ERJ open research · 2025Review
- Mild intermittent hypoxia may improve autonomic dysfunction in persons living with spinal cord injury: a preliminary snapshot.Frontiers in neuroscience · 2025Article
- Role of sleep disorders in patients with cardiovascular disease: A systematic review.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- A Narrative Review of the Association of Obstructive Sleep Apnea with Hypertension: How to Treat Both When They Coexist?Journal of clinical medicine · 2023Review
- Research trends in hypertension associated with obstructive sleep apnea: a bibliometric analysis.Sleep & breathing = Schlaf & Atmung · 2023Review
- Association between Previous CPAP and Comorbidities at Diagnosis of Obesity-Hypoventilation Syndrome Associated with Obstructive Sleep Apnea: A Comparative Retrospective Observational Study.Journal of clinical medicine · 2023Article
- ANGPTL3 and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea.Journal of the American Heart Association · 2022Article
- Current and novel treatment options for obstructive sleep apnoea.ERJ open research · 2022Review
- High-sensitive cardiac troponin after CPAP in obstructive sleep apnoea: the adjusted analytical change limit (adjACL) for small variations at low concentrations.The European respiratory journal · 2022Article
- Obstructive sleep apnea in hypertension evaluation: An underutilized component of cardiovascular risk assessment.JRSM cardiovascular diseaseArticle
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of treatment for obstructive sleep apnoea (OSA) on reduction of cardiovascular risk is unclear. This study aimed to examine the effect of continuous positive airway pressure (CPAP) on ambulatory blood pressure (BP) and subclinical myocardial injury in subjects with OSA and hypertension.
methodsThis was a parallel-group randomised controlled trial. Subjects with hypertension requiring at least three antihypertensive medications and moderate-to-severe OSA were enrolled. Eligible subjects were randomised (1:1) to receive either CPAP treatment or control (no CPAP) for 8 weeks. Changes in ambulatory BP and serum biomarkers were compared. Stratified analysis according to circadian BP pattern was performed.
results92 subjects (75% male; mean±sd age 51±8 years and apnoea-hypopnoea index 40±8 events·h
conclusionsIn a cohort with OSA and multiple cardiovascular risk factors including difficult-to-control hypertension, short-term CPAP treatment improved ambulatory BP, and alleviated subclinical myocardial injury and strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.