ArticleThe European respiratory journal2021
Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach.
Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Paternal preconception modifiable risk factors for adverse pregnancy and offspring outcomes: a review of contemporary evidence from observational studies.BMC public health · 2023Pooled it
- Paternal snus use in puberty and increased risk for asthma and allergies in offspring: a RHINE/RHINESSA two-generation study.International journal of epidemiology · 2026Article
- Multifaceted paternal exposures before conception and their epigenetic impact on offspring.Journal of assisted reproduction and genetics · 2024Review
- Air Pollution and Bronchitis: Childhood Exposure, Lifelong Consequences.American journal of respiratory and critical care medicine · 2024Article
- Maternal exposure to smoking and wheezing phenotypes in children: a cohort study of the Japan Environment and Children's Study.BMC pediatrics · 2024Article
- Exploring the genetics of airflow limitation in lung function across the lifespan - a polygenic risk score study.EClinicalMedicine · 2024Article
- To burn or not to burn: similar effects of different types of prenatal tobacco exposure on infant lung function.ERJ open research · 2024Article
- ERS International Congress 2023: highlights from the Respiratory Infections Assembly.ERJ open research · 2024Article
- Unveiling the hidden risk: paternal smoking and alcohol exposure prior to conception as independent factors for allergic rhinitis in children.Frontiers in pediatrics · 2024Article
- Fathers' preconception smoking and offspring DNA methylation.Clinical epigenetics · 2023Article
- Developmental origins of health and disease: Impact of paternal nutrition and lifestyle.Pediatric investigation · 2023Review
- Antenatal Care and Health Behavior of Pregnant Women-An Evaluation of the Survey of Neonates in Pomerania.Children (Basel, Switzerland) · 2023Article
- An epigenetic synopsis of parental substance use.Epigenomics · 2023Review
- The role of epigenetics in multi-generational transmission of asthma: An NIAID workshop report-based narrative review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Historical Redlining Impacts Contemporary Environmental and Asthma-related Outcomes in Black Adults.American journal of respiratory and critical care medicine · 2022Article
- Association of advanced paternal age with lung function at school age.Respiratory research · 2022Article
- Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission.Lancet (London, England) · 2022Review
- Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort.BMJ open · 2022Article
- Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan.The Lancet. Respiratory medicine · 2022Review
- Parental Prepuberty Overweight and Offspring Lung Function.Nutrients · 2022Article
Corrections and comments
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Authors and funding
22 authors at 15 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanistic research suggests that lifestyle and environmental factors impact respiratory health across generations by epigenetic changes transmitted through male germ cells. Evidence from studies on humans is very limited.We investigated multigeneration causal associations to estimate the causal effects of tobacco smoking on lung function within the paternal line. We analysed data from 383 adult offspring (age 18-47 years; 52.0% female) and their 274 fathers, who had participated in the European Community Respiratory Health Survey (ECRHS)/Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study and had provided valid measures of pre-bronchodilator lung function. Two counterfactual-based, multilevel mediation models were developed with: paternal grandmothers' smoking in pregnancy and fathers' smoking initiation in prepuberty as exposures; fathers' forced expiratory volume in 1 s (FEV
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.