ArticleBMJ open2021
Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 11 citations in OpenAlex.
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- Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.BMJ open diabetes research & care · 2026Article
- Early insights from the Healthy Life Trajectories Initiative.Bulletin of the World Health Organization · 2026Article
- Gender-related perceptions among healthcare providers and mothers in a pregnancy and early childhood obesity prevention intervention in Shanghai, China.International journal for equity in health · 2026Article
- Sino-Canadian Healthy Life Trajectories Initiative in China: an economic evaluation protocol.BMJ open · 2026Article
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- A stepwise approach to designing and delivering the SCHeLTI trial community-family-mother-child obesity prevention intervention.MethodsX · 2025Article
- Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.Lancet (London, England) · 2025Article
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- Postpartum weight retention and the early evolution of cardiovascular risk over the first 5 years after pregnancy.Cardiovascular diabetology · 2024Observational
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- Developing Policy for the Healthy Life Trajectories Initiative: Going from National to International.Biopreservation and biobanking · 2023Article
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- Development, Implementation, and Process Evaluation ofGlobal implementation research and applications · 2023Article
- Breastfeeding Practices and Associated Factors in Shanghai: A Cross-Sectional Study.Nutrients · 2022Article
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Authors and funding
53 authors at 17 institutions in 2 countries.
Funding
Abstract
introductionChildhood overweight and obesity (OWO) is a primary global health challenge. Childhood OWO prevention is now a public health priority in China. The Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI), one of four trials being undertaken by the international HeLTI consortium, aims to evaluate the effectiveness of a multifaceted, community-family-mother-child intervention on childhood OWO and non-communicable diseases risk. METHODS AND ANALYSIS: This is a multicentre, cluster-randomised, controlled trial conducted in Shanghai, China. The unit of randomisation is the service area of Maternal Child Health Units (N=36). We will recruit 4500 women/partners/families in maternity and district level hospitals. Participants in the intervention group will receive a multifaceted, integrated package of health promotion interventions beginning in preconception or in the first trimester of pregnancy, continuing into infancy and early childhood. The intervention, which is centred on a modified motivational interviewing approach, will target early-life maternal and child risk factors for adiposity. Through the development of a biological specimen bank, we will study potential mechanisms underlying the effects of the intervention. The primary outcome for the trial is childhood OWO (body mass index for age ≥85th percentile) at 5 years of age, based on WHO sex-specific standards. The study has a power of 0.8 (α=0.05) to detect a 30% risk reduction in the proportion of children with OWO at 5 years of age, from 24.4% in the control group to 17% in the intervention group. Recruitment was launched on 30 August 2018 for the pilot study and 10 January 2019 for the formal study. ETHICS AND DISSEMINATION: The study has been approved by the Medical Research Ethics Committee of the International Peace Maternity and Child Health Hospital in Shanghai, China, and the Research Ethics Board of the Centre Intégré Universitaire de Santé et Services Sociaux de l'Estrie-CHUS in Sherbrooke, Canada. Data sharing policies are consistent with the governance policy of the HeLTI consortium and government legislation. TRIAL REGISTRATION NUMBER: ChiCTR1800017773. PROTOCOL VERSION: November 11, 2020 (Version #5).
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