ArticleBMJ open2021
Cohort profile: Understanding Pregnancy Signals and Infant Development (UPSIDE): a pregnancy cohort study on prenatal exposure mechanisms for child health.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 50 citations in OpenAlex.
- Maternal mycoestrogen exposure in relation to timing of birth and placental corticotropin releasing hormone concentrations in a U.S. pregnancy cohort.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Prenatal exposure to organophosphate ester flame retardants and plasticizers and maternal immune responses in three ECHO cohorts.Environmental research · 2026Article
- In Utero Per- and Polyfluoroalkyl Substances (PFAS) Exposure and Changes in Infant T Helper Cell Development among UPSIDE-ECHO Cohort Participants.Environmental health perspectives · 2026Article
- Early-life gut microbiome composition and rotavirus vaccine-induced IgA responses in U.S. infants: a longitudinal cohort study.EBioMedicine · 2026Article
- Maternal depression with and without a history of childhood maltreatment and newborn white matter microstructure.Psychological medicine · 2026Article
- Organophosphate ester exposure in pregnancy, gestational weight gain, and postpartum body composition in a U.S.-based longitudinal pregnancy cohort.Environmental health : a global access science source · 2025Article
- Prenatal air pollution exposure and placental vasculature development among participants of the UPSIDE cohort study.Environmental research · 2025Article
- PMAir quality, atmosphere, & health · 2025Article
- Timing sensitivity of prenatal cortisol exposure and neurocognitive development.Development and psychopathology · 2025Article
- Sociodemographic and dietary predictors of maternal and placental mycoestrogen concentrations in a US pregnancy cohort.Journal of exposure science & environmental epidemiology · 2025Article
- The role of prenatal maternal sex steroid hormones in weight and adiposity at birth and growth trajectories during infancy.International journal of obesity (2005) · 2025Article
- Mycoestrogen Exposure during Pregnancy: Impact of theEnvironmental health perspectives · 2025Article
- Maternal organophosphate esters and sex steroid hormones in mid-pregnancy.Environmental research · 2025Article
- Gestational exposure to PMEnvironmental epidemiology (Philadelphia, Pa.) · 2025Article
- Benzo[Environmental science. Processes & impacts · 2025Article
- Article
- Prenatal exposure to phthalates and phthalate replacements in relation to chorionic plate surface vasculature at delivery.The Science of the total environment · 2025Article
- Affective symptoms in pregnancy are associated with the vaginal microbiome.Journal of affective disorders · 2025Article
- Feeding Expressed Breast Milk Alters the Microbial Network of Breast Milk and Increases Breast Milk Microbiome Diversity over Time.Microorganisms · 2024Article
- INSIGHT-2: mechanistic studies into pregnancy complications and their impact on maternal and child health-study protocol.Reproductive health · 2024Article
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
purposeExtensive research suggests that maternal prenatal distress is reliably related to perinatal and child health outcomes-which may persist into adulthood. However, basic questions remain regarding mechanisms involved. To better understand these mechanisms, we developed the Understanding Pregnancy Signals and Infant Development (UPSIDE) cohort study, which has several distinguishing features, including repeated assessments across trimesters, analysis of multiple biological pathways of interest, and incorporation of placental structure and function as mediators of child health outcomes.
participantsWomen with normal risk pregnancies were recruited at <14 weeks gestation. Study visits occurred in each trimester and included extensive psychological, sociodemographic, health behaviour and biospecimen collection. Placenta and cord blood were collected at birth. Child visits (ongoing) occur at birth and 1, 6, 12, 24, 36 and 48 months of age and use standard anthropometric, clinical, behavioural, biological and neuroimaging methods to assess child physical and neurodevelopment. FINDINGS TO DATE: We recruited 326 pregnancies; 294 (90%) were retained through birth. Success rates for prenatal biospecimen collection were high across all trimesters (96%-99% for blood, 94%-97% for urine, 96%-99% for saliva, 96% of placentas, 88% for cord blood and 93% for buccal swab). Ninety-four per cent of eligible babies (n=277) participated in a birth examination; postnatal visits are ongoing. FUTURE PLANS: The current phase of the study follows children through age 4 to examine child neurodevelopment and physical development. In addition, the cohort participates in the National Institutes of Health's Environmental influences on Child Health Outcomes programme, a national study of 50 000 families examining early environmental influences on perinatal outcomes, neurodevelopment, obesity and airway disease. Future research will leverage the rich repository of biological samples and clinical data to expand research on the mechanisms of child health outcomes in relation to environmental chemical exposures, genetics and the microbiome.
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