Evidence map›Paper›PMID 33795188›Full record

ArticleJournal of cardiovascular computed tomography

CTA pulmonary artery enlargement in patients with severe aortic stenosis: Prognostic impact after TAVR.

Valery L Turner, Ayman Jubran, Juyong Brian Kim, Eva Maret, Kegan J Moneghetti, Francois Haddad, Myriam Amsallem, Marina Codari, Virginia Hinostroza, Domenico Mastrodicasa and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 2 countries.

Valery L TurnerDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: vturner@stanford.edu.
Ayman JubranDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: Ayman.jubran@gmail.com.
Juyong Brian KimDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: kimjb@stanford.edu.
Eva MaretDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA; Department of Clinical Physiology, Karolinska University Hospital, Karolinska Institute, Stockholm. Electronic address: evamaret@gmail.com.
Kegan J MoneghettiDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: keganm@stanford.edu.
Francois HaddadDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: fhaddad@stanford.edu.
Myriam AmsallemDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: mamsalle@stanford.edu.
Marina CodariDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: mcodari@stanford.edu.
Virginia HinostrozaDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: vhinostr@stanford.edu.
Domenico MastrodicasaDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: mastro@stanford.edu.
Anna M SailerDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: anna.karmann@stanford.edu.
Yukari KobayashiDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: yukariko@stanford.edu.
Takeshi NishiDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: takeshi24@hotmail.co.jp.
Alan C YeungDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: ayeung@stanford.edu.
Amelia C WatkinsDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: acwat@stanford.edu.
Anson M LeeStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: ansonlee@stanford.edu.
D Craig MillerStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: dcm@stanford.edu.
Michael P FischbeinStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: mfischbe@stanford.edu.
William F FearonDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: wfearon@stanford.edu.
Martin J WilleminkDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: M.J.Willemink@stanford.edu.
Dominik FleischmannDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: d.fleischmann@stanford.edu.
Cardiovascular Institute of the South · USStanford Medicine · USKarolinska University Hospital · SE

Funding

Multi-Disciplinary Training Program in Cardiovascular Imaging at StanfordT32EB009035 · NIBIB · STANFORD UNIVERSITY · PI Koen Nieman, John M. Pauly · 2008 to 2026
$4.3M
NIBIB NIH HHS T32 EB009035
6 · The paper itself

Abstract

backgroundIdentifying high-risk patients who will not derive substantial survival benefit from TAVR remains challenging. Pulmonary hypertension is a known predictor of poor outcome in patients undergoing TAVR and correlates strongly with pulmonary artery (PA) enlargement on CTA. We sought to evaluate whether PA enlargement, measured on pre-procedural computed tomography angiography (CTA), is associated with 1-year mortality in patients undergoing TAVR.

methodsWe retrospectively included 402 patients undergoing TAVR between July 2012 and March 2016. Clinical parameters, including Society of Thoracic Surgeons (STS) score and right ventricular systolic pressure (RVSP) estimated by transthoracic echocardiography were reviewed. PA dimensions were measured on pre-procedural CTAs. Association between PA enlargement and 1-year mortality was analyzed. Kaplan-Meier and Cox proportional hazards regression analyses were performed.

resultsThe median follow-up time was 433 (interquartiles 339-797) days. A total of 56/402 (14%) patients died within 1 year after TAVR. Main PA area (area-MPA) was independently associated with 1-year mortality (hazard ratio per standard deviation equal to 2.04 [95%-confidence interval (CI) 1.48-2.76], p ​< ​0.001). Area under the curve (95%-CI) of the clinical multivariable model including STS-score and RVSP increased slightly from 0.67 (0.59-0.75) to 0.72 (0.72-0.89), p ​= ​0.346 by adding area-MPA. Although the AUC increased, differences were not significant (p ​= ​0.346). Kaplan-Meier analysis showed that mortality was significantly higher in patients with a pre-procedural non-indexed area-MPA of ≥7.40 ​cm

conclusionsEnlargement of MPA on pre-procedural CTA is independently associated with 1-year mortality after TAVR.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAortic ValveComputed Tomography AngiographyHumansKaplan-Meier EstimatePredictive Value of TestsPrognosisPulmonary ArteryRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeAortic valve stenosisComputed tomography angiographyPulmonary arteryPulmonary hypertensionTranscatheter aortic valve replacement

Identifiers

PMID33795188
PMCPMC10017114
OpenAlexW3138847096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.