ArticleMicrobiome2021
Combined effects of composting and antibiotic administration on cattle manure-borne antibiotic resistance genes.
Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- An Overview of Antibiotic Resistance and Abiotic Stresses Affecting Antimicrobial Resistance in Agricultural Soils.International journal of environmental research and public health · 2022Pooled it
- Transmission and Evolution of Antibiotic Resistance Genes and Antibiotic-Resistant Bacteria in Animals, Food, Humans and the Environment.Microorganisms · 2026Review
- Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods.Communications medicine · 2025Article
- Harnessing beneficial bacteria to remediate antibiotic-polluted agricultural soils: integrating source diversity, bioavailability modulators, and ecological impacts.Frontiers in microbiology · 2025Review
- Characterization of antibiotic resistance genes in soils from agroecosystems of the Brazilian Amazon.Frontiers in microbiology · 2025Article
- MetaCompare 2.0: differential ranking of ecological and human health resistome risks.FEMS microbiology ecology · 2024Article
- When the solution becomes the problem: a review on antimicrobial resistance in dairy cattle.Future microbiology · 2024Review
- Composting reduces the risks of resistome in beef cattle manure at the transcriptional level.Applied and environmental microbiology · 2024Article
- Effects ofApplied and environmental microbiology · 2024Article
- Microbial antibiotic resistance genes across an anthropogenic gradient in a Canadian High Arctic watershed.Sustainable microbiology · 2024Article
- Metagenomic Profiles of Yak and Cattle Manure Resistomes in Different Feeding Patterns before and after Composting.Applied and environmental microbiology · 2023Article
- Current and Future Flow Cytometry Applications Contributing to Antimicrobial Resistance Control.Microorganisms · 2023Review
- Impact of Anthropogenic Activities on the Dissemination of ARGs in the Environment-A Review.International journal of environmental research and public health · 2022Review
- Current status and future perspective of antimicrobial-resistant bacteria and resistance genes in animal-breeding environments.The Journal of veterinary medical science · 2022Review
- Metagenomic assembly reveals hosts and mobility of common antibiotic resistome in animal manure and commercial compost.Environmental microbiome · 2022Article
- Metagenomic tracking of antibiotic resistance genes through a pre-harvest vegetable production system: an integrated lab-, microcosm- and greenhouse-scale analysis.Environmental microbiology · 2022Article
- Antimicrobial Resistance in New Zealand-A One Health Perspective.Antibiotics (Basel, Switzerland) · 2022Review
- Lagoon, Anaerobic Digestion, and Composting of Animal Manure Treatments Impact on Tetracycline Resistance Genes.Antibiotics (Basel, Switzerland) · 2022Review
- Enhancing control of multidrug-resistant plasmid and its host community with a prolonged thermophilic phase during composting.Frontiers in microbiology · 2022Article
- Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch is needed to delineate the relative and combined effects of different antibiotic administration and manure management practices in either amplifying or attenuating the potential for antibiotic resistance to spread. Here, we carried out a comprehensive parallel examination of the effects of small-scale (> 55 °C × 3 days) static and turned composting of manures from dairy and beef cattle collected during standard antibiotic administration (cephapirin/pirlimycin or sulfamethazine/chlortetracycline/tylosin, respectively), versus from untreated cattle, on "resistomes" (total antibiotic resistance genes (ARGs) determined via shotgun metagenomic sequencing), bacterial microbiota, and indicator ARGs enumerated via quantitative polymerase chain reaction. To gain insight into the role of the thermophilic phase, compost was also externally heated to > 55 °C × 15 days.
resultsProgression of composting with time and succession of the corresponding bacterial microbiota was the overarching driver of the resistome composition (ANOSIM; R = 0.424, p = 0.001, respectively) in all composts at the small-scale. Reduction in relative abundance (16S rRNA gene normalized) of total ARGs in finished compost (day 42) versus day 0 was noted across all conditions (ANOSIM; R = 0.728, p = 0.001), except when externally heated. Sul1, intI1, beta-lactam ARGs, and plasmid-associated genes increased in all finished composts as compared with the initial condition. External heating more effectively reduced certain clinically relevant ARGs (bla
conclusionsThis comprehensive, integrated study revealed that composting had a dominant effect on corresponding resistome composition, while little difference was noted as a function of collecting manure during antibiotic administration. Reduction in total ARGs, tet(W), and resistome risk suggested that composting reduced some potential for antibiotic resistance to spread, but the increase and persistence of other indicators of antibiotic resistance were concerning. Results indicate that composting guidelines intended for pathogen reduction do not necessarily provide a comprehensive barrier to ARGs or their mobility prior to land application and additional mitigation measures should be considered. Video Abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.