ArticleBiotechnology for biofuels2021
Discovery of two novel laccase-like multicopper oxidases from Pleurotus citrinopileatus and their application in phenolic oligomer synthesis.
Article in Biotechnology for biofuels, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Comparative proteome profiling of egg, larva and adult Hermetia illucens (Diptera: Stratiomyidae).Scientific reports · 2025Article
- Genomic, Proteomic, and Biochemical Study ofJournal of agricultural and food chemistry · 2025Article
- Specific Phenylpropanoid Oligomerization in a Neutral Environment by the Recombinant Alkaline Laccase fromBiomolecules · 2025Article
- Tailoring hyaluronic acid hydrogels: Impact of cross-linker length and density on skin rejuvenation as injectable dermal fillers and their potential effects on the MAPK signaling pathway suppression.Bioactive materials · 2025Article
- Elucidating Thermothielavioides terrestris secretome changes for improved saccharification of mild steam-pretreated spruce.Biotechnology for biofuels and bioproducts · 2024Article
- White Rot Fungi as Tools for the Bioremediation of Xenobiotics: A Review.Journal of fungi (Basel, Switzerland) · 2024Review
- Role and structure of the small subunit forming heterodimers with laccase-like enzymes.Protein science : a publication of the Protein Society · 2023Article
- Transcriptomic Analysis of Acetaminophen Biodegradation byJournal of fungi (Basel, Switzerland) · 2023Article
- Efficient Degradation of Aflatoxin BToxins · 2021Article
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Abstract
backgroundLaccases and laccase-like multicopper oxidases (LMCOs) oxidize a vast array of phenolic compounds and amines, releasing water as a byproduct. Their low substrate specificity is responsible for their tremendous biotechnological interest, since they have been used for numerous applications. However, the laccases characterized so far correspond to only a small fraction of the laccase genes identified in fungal genomes. Therefore, the knowledge regarding the biochemistry and physiological role of minor laccase-like isoforms is still limited.
resultsIn the present work, we describe the isolation, purification and characterization of two novel LMCOs, PcLac1 and PcLac2, from Pleurotus citrinopileatus. Both LMCOs were purified with ion-exchange chromatographic methods. PcLac2 was found to oxidize a broader substrate range than PcLac1, but both LMCOs showed similar formal potentials, lower than those reported previously for laccases from white-rot fungi. Proteomic analysis of both proteins revealed their similarity with other well-characterized laccases from Pleurotus strains. Both LMCOs were applied to the oxidation of ferulic and sinapic acid, yielding oligomers with possible antioxidant activity.
conclusionsOverall, the findings of the present work can offer new insights regarding the biochemistry and variability of low-redox potential laccases of fungal origin. Low-redox potential biocatalysts could offer higher substrate selectivity than their high-redox counterparts, and thus, they could be of applied value in the field of biocatalysis.
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