Observational studyPediatric rheumatology online journal2021
Epidemiology of pediatric uveitis and associated systemic diseases.
Observational study in Pediatric rheumatology online journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Is There a Link between the Molecular Basis of Juvenile Idiopathic Arthritis and Autoimmune Diseases? Systematic Review.International journal of molecular sciences · 2024Pooled it
- Immune-Mediated Inflammatory Diseases Following Pediatric Uveitis Diagnosis.JAMA network open · 2026Article
- Uveitis associated with juvenile idiopathic arthritis and chronic idiopathic uveitis in children: A retrospective cohort study.World journal of clinical pediatrics · 2025Article
- Epidemiology of Uveitis from a Tertiary Referral Hospital in Bulgaria over a 13-Year Period.Diagnostics (Basel, Switzerland) · 2025Article
- Risk of uveitis among children with autoimmune diseases: a nationwide matched-cohort study of 3,643 cases.Frontiers in immunology · 2025Article
- "Infectious uveitis: a comprehensive systematic review of emerging trends and molecular pathogenesis using network analysis".Journal of ophthalmic inflammation and infection · 2024Review
- Clinical characteristics of pediatric noninfectious uveitis and risk factors for severe disease: a single-center study.Clinical rheumatology · 2024Article
- Paediatric Uveitis - the uniqueness in clinical presentation and the efficacy of biologics treatment.Journal of ophthalmic inflammation and infection · 2024Article
- Diagnosis and Treatment of Uveitis in Children: A Summary of the Latest Data from a 5-Year Literature Review (2018-2023).Journal of clinical medicine · 2024Review
- Uveitis Profile in Children and Its Impact on Vision at Queen Rania Children's Hospital.Cureus · 2024Article
- An Overview of Pediatric Uveitis.Turkish archives of pediatrics · 2023Article
- Incidence and Prevalence of Pediatric Noninfectious Uveitis in Korea: A Population-Based Study.Journal of Korean medical science · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe early detection of uveitis associated with systemic inflammatory disease in children is important for proper treatment and prognosis. However, the diagnosis may be delayed because of difficulties in childhood examinations and early minor systemic symptoms. The objective of our study was to identify the pattern of childhood uveitis and investigate the frequency and clinical features of rheumatic diseases in pediatric patients with uveitis.
methodsThis retrospective observational study reviewed the medical records of children (age ≤ 18 years) with uveitis at a Korean tertiary hospital between January 2005 and December 2018. Data collected included the age at onset of uveitis, sex, anatomic location of ocular inflammation, comorbid disease (including systemic inflammatory disease), ocular complications, relevant laboratory data, and treatment. Fisher's exact test was used to compare categorical variables and the Mann-Whitney U test was used to compare continuous variables. A p-value of < 0.05 was considered statistically significant.
resultsA total of 155 pediatric patients with uveitis were included in this study. The median age at diagnosis was 13.0 years (interquartile range, 9.5-16.0 years). The male-to-female ratio was 1.09. The process was unilateral in 51.6% of children. Anterior uveitis, panuveitis, intermediate uveitis, and posterior uveitis represented 51.6, 26.5, 6.5, and 1.9% of the cases, respectively. Idiopathic uveitis (65.2%) was the most frequent type of uveitis. Systemic rheumatic disease associations were responsible for 28.4% of the cases, among which juvenile idiopathic arthritis (JIA) was the most frequent cause (14.8%). Human leukocyte antigen (HLA)-B27 and antinuclear antibody (ANA) positive rates were significantly higher in patients with JIA than in those with idiopathic uveitis (p = 0.006 and p = 0.007, respectively).
conclusionsApproximately one-third of children with uveitis in Korea have a systemic rheumatic disease, of which JIA accounts for the majority of cases. HLA-B27 and ANA can serve as risk factors for JIA-associated uveitis.
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