SynthesisBMC complementary medicine and therapies2021
Acupuncture for post-stroke depression: a systematic review and meta-analysis.
Synthesis in BMC complementary medicine and therapies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Clinical efficacy study on the combined treatment of cancer-related depression with traditional Chinese acupuncture-related therapies and drugs.Frontiers in psychiatry · 2025Pooled it
- Neuroimaging evidence of acupuncture in cognitive impairment following ischemic stroke: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Electroacupuncture for post-stroke depression: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2025Pooled it
- Efficacy and safety of acupuncture on sleep quality for post-stroke insomnia: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Use of Acupuncture for Adult Health Conditions, 2013 to 2021: A Systematic Review.JAMA network open · 2022Pooled it
- The efficacy of therapies for post-stroke depression in aging: An umbrella review.Frontiers in aging neuroscience · 2022Pooled it
- Acupuncture plus wet cupping therapy for post stroke depression: a randomized controlled trial.Frontiers in psychiatry · 2026Trial
- Frequency-dependent alterations of degree centrality in patients with poststroke depression: a resting-state functional MRI study.Neuroreport · 2026Article
- Central Neurobiological Mechanisms of Acupuncture in Post-Stroke Depression: Multi-Target and Network-Based Regulation.Neuropsychiatric disease and treatment · 2026Review
- Acupuncture and Moxibustion for Poststroke Depression: Systematic Review.Interactive journal of medical research · 2025Review
- The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression.Translational psychiatry · 2025Article
- Antidepressant-Like Effects of Electroacupuncture by Regulating NLRP3-mediated Hippocampal Inflammation and Pyroptosis in Rats With Post-Stroke Depression.Brain and behavior · 2025Article
- Effectiveness and Safety of Acupuncture as an Adjunctive Therapy for Post-Stroke Depression: An Overview of Systematic Reviews.Neuropsychiatric disease and treatment · 2025Review
- Efficacy and safety of acupuncture treatment for post-stroke depression: A protocol for systematic review and meta-analysis.PloS one · 2024Article
- Electroacupuncture versus Escitalopram for mild to moderate Post-Stroke Depression: A randomized non-inferiority trial.Frontiers in psychiatry · 2024Article
- Efficacy of acupuncture in the treatment of post-stroke depression: A study protocol of a randomized controlled trial.PloS one · 2024Article
- Efficacy and safety of acupuncture for post-COVID-19 depression: a protocol for systematic review and meta-analysis.BMJ open · 2023Article
- Effectiveness of acupuncture treatment for stroke and stroke complications: a protocol for meta-analysis and systematic review based on randomized, single-blind, controlled trials.Frontiers in neurology · 2023Article
- Electroacupuncture treatment ameliorates depressive-like behavior and cognitive dysfunction via CB1R dependent mitochondria biogenesis after experimental global cerebral ischemic stroke.Frontiers in cellular neuroscience · 2023Article
- Effects of Optimized Acupuncture and Moxibustion Treatment on Depressive Symptoms and Executive Functions in Patients With Post-Stroke Depression: Study Protocol for a Randomized Controlled Trial.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAcupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized clinical trials (RCTs) of acupuncture for PSD, we sought to draw conclusions by synthesizing RCTs.
methodsAn exhaustive literature search was conducted in seven electronic databases from their inception dates to April 19, 2020, to identify systematic reviews (SRs) and meta-analyses (MAs) on this topic. The primary RCTs included in the SRs/MAs were identified. We also conducted a supplementary search for RCTs published from January 1, 2015, to May 12, 2020. Two reviewers extracted data separately and pooled data using RevMan 5.3 software. The quality of evidence was critically appraised with the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system.
resultsA total of 17 RCTs involving 1402 patients were included. Meta-analysis showed that participants who received a combination of acupuncture and conventional treatments exhibited significantly lower scores on the HAM-D
conclusionsThe current review indicates that acupuncture has greater effect on PSD and better safety profile than antidepressants, but high-quality evidence evaluating acupuncture for PSD is still needed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.