Evidence map›Paper›PMID 33794786›Full record

ArticleBMC geriatrics2021

Perceived walking difficulties in Parkinson's disease - predictors and changes over time.

Magnus Lindh-Rengifo, Stina B Jonasson, Susann Ullén, Niklas Mattsson-Carlgren, Maria H Nilsson

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06707402 (The Effects of 24 Weeks Community-based Brisk Walking on Physical Function, Comorbidities, Cognition, Disease Severity, and Health-related Quality of Life in People With Parkinson's Disease.), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06707402 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of 24 Weeks Community-based Brisk Walking on Physical Function, Comorbidities, Cognition, Disease Severity, and Health-related Quality of Life in People With Parkinson's Disease.

TypeinterventionalSponsorUniversity of AarhusRan2025 to 2027Enrolled129ConditionsParkinson DiseaseArmsWALK, ACTIVE, CON
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Magnus Lindh-RengifoDepartment of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden. magnus.lindh-rengifo@med.lu.se.ORCID 0000-0002-2336-4881
Stina B JonassonMemory Clinic, Skåne University Hospital, Malmö, Sweden.ORCID 0000-0003-4774-4034
Susann UllénClinical Studies Sweden - Forum South, Skåne University Hospital, Lund, Sweden.ORCID 0000-0003-4854-9230
Niklas Mattsson-CarlgrenClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.ORCID 0000-0002-8885-7724
Maria H NilssonDepartment of Health Sciences, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0002-6580-6721
Lund University · SESkåne University Hospital · SE

Funding

Vetenskapsrådet 2017-01541
6 · The paper itself

Abstract

backgroundPeople with Parkinson's disease (PD) have described their walking difficulties as linked to activity avoidance, social isolation, reduced independence and quality of life. There is a knowledge gap regarding predictive factors of perceived walking difficulties in people with PD. Such knowledge could be useful when designing intervention studies. This study aimed to investigate how perceived walking difficulties evolve over a 3-year period in people with PD. A specific aim was to identify predictive factors of perceived walking difficulties.

methodsOne hundred forty-eight people with PD (mean age 67.9 years) completed the Generic Walk-12 (Walk-12G) questionnaire (which assesses perceived walking difficulties) at both baseline and the 3-year follow-up. Paired samples t-test was used for comparing baseline and follow-up mean scores. Multivariable linear regression analyses were used to identify predictive factors of perceived walking difficulties.

resultsPerceived walking difficulties increased after 3 years: mean Walk-12G score 14.8 versus 18.7, p < 0.001. Concerns about falling was the strongest predictor (β = 0.445) of perceived walking difficulties, followed by perceived balance problems while dual tasking (β = 0.268) and pain (β = 0.153). Perceived balance problems while dual tasking was the strongest predictor (β = 0.180) of a change in perceived walking difficulties, followed by global cognitive functioning (β = - 0.107).

conclusionsPerceived walking difficulties increase over time in people with PD. Both personal factors (i.e. concerns about falling) and motor aspects (i.e. balance problems while dual tasking) seem to have a predictive role. Importantly, our study indicates that also non-motor symptoms (e.g. pain and cognitive functioning) seem to be of importance for future perceived walking difficulties. Future intervention studies that address these factors need to confirm their preventative effect on perceived walking difficulties.

Indexed as

Parkinson DiseaseWalkingAccidental FallsAgedHumansMobility LimitationQuality of LifeMobility limitationMultivariable regressionParkinson diseasePerceived walking difficultiesPrediction

Identifiers

PMID33794786
PMCPMC8015068
OpenAlexW3135364452

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.