Evidence map›Paper›PMID 33794735›Full record

ArticleGut microbes

The Impact of Migration on the Gut Metagenome of South Asian Canadians.

Julia K Copeland, Gary Chao, Shelley Vanderhout, Erica Acton, Pauline W Wang, Eric I Benchimol, Ahmed El Sohami, Ken Croitoru, Jennifer L Gommerman, David S Guttman and 1 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Examining the healthy human microbiome concept.Nature reviews. Microbiology · 2025
    Review
  8. Article
  9. Migration Spurs Changes in the Human Microbiome: a Review.Journal of racial and ethnic health disparities · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Delayed colonization ofFrontiers in pediatrics · 2024
    Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Review
  20. Intercontinental Gut Microbiome Variances in IBD.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Julia K CopelandCentre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, CA, Canada.
Gary ChaoDepartment of Immunology, University of Toronto, Toronto, CA, Canada.
Shelley VanderhoutNutrigenomix, Department of Nutritional Sciences, University of Toronto, Toronto, CA, Canada.
Erica ActonCentre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, CA, Canada.
Pauline W WangCentre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, CA, Canada.
Eric I BenchimolDepartment of Pediatrics, and School of Epidemiology and Public Health, University of Ottawa, Ottawa, CA, Canada.
Ahmed El SohamiDepartment of Nutritional Sciences, University of Toronto, Toronto, CA, Canada.
Ken CroitoruDepartment of Medicine, University of Toronto and Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, CA, Canada.
Jennifer L GommermanDepartment of Immunology, University of Toronto, Toronto, CA, Canada.
David S GuttmanCentre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, CA, Canada.
GEMINI Research Team
University of Toronto · CAMount Sinai Hospital · CAUniversity of Ottawa · CA

Funding

CIHR
6 · The paper itself

Abstract

South Asian (SA) Canadian immigrants have a higher risk of developing certain immune-mediated inflammatory diseases compared to non-migrant SAs. We sought to investigate the effect of migration on the gut metagenome and to identify microbiological associations between migration and conditions that may influence the development of immune-mediated inflammatory diseases. Metagenomic analysis of 58 first-generation (GEN1) SA immigrants and 38 unrelated Canadian born children-of-immigrants (GEN2) determined that the time lived in Canada was associated with continued changes in gut microbial communities. Migration of GEN1 to Canada early in life results in a gut community with similarities to GEN2 SA Canadians and non-SA North Americans. Conversely, GEN1 immigrants who arrived recently to Canada exhibited pronounced differences from GEN2, while displaying microbial similarities to a non-migrating SA cohort. Multivariate analysis identified that community composition was primarily influenced by high abundance taxa.

Indexed as

Gastrointestinal MicrobiomeMetagenomeAdolescentAdultAsian PeopleBacteriaBiodiversityCanadaCohort StudiesDietDNA, BacterialEmigrants and ImmigrantsFecesFemaleHigh-Throughput Nucleotide SequencingHumansDNA, BacterialdialisterGut metagenomeimmigrationimmune-mediated inflammatory diseaseprevotellascfa

Identifiers

PMID33794735
PMCPMC8023248
OpenAlexW3147713100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.