Evidence map›Paper›PMID 33794697›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2021

Variable number tandem repeats - Their emerging role in sickness and health.

Jack Ng Marshall, Ana Illera Lopez, Abigail L Pfaff, Sulev Koks, John P Quinn, Vivien J Bubb

Open access · hybridAbstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Genetic modifiers of repeat expansion disorders.Emerging topics in life sciences · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Frontiers in genetics · 2022
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jack Ng MarshallDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Ana Illera LopezDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Abigail L PfaffPerron Institute for Neurological and Translational Science, Perth, WA 6009, Australia.ORCID 0000-0002-2231-9800
Sulev KoksPerron Institute for Neurological and Translational Science, Perth, WA 6009, Australia.ORCID 0000-0001-6087-6643
John P QuinnDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.
Vivien J BubbDepartment of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0003-2763-7004
University of Liverpool · GBMurdoch University · AU

Funding

Medical Research Council MR/N013840/1Wellcome TrustWellcome Trust 109095/Z/15/Z
6 · The paper itself

Abstract

Understanding the mechanisms regulating tissue specific and stimulus inducible regulation is at the heart of understanding human biology and how this translates to wellbeing, the ageing process, and disease progression. Polymorphic DNA variation is superimposed as an extra layer of complexity in such processes which underpin our individuality and are the focus of personalized medicine. This review focuses on the role and action of repetitive DNA, specifically variable number tandem repeats and SINE-VNTR-

Indexed as

AnimalsGene ExpressionHumansPolymorphism, GeneticTandem Repeat Sequencesneurological diseasephysiologySVAtranscriptional regulationVNTR

Identifiers

PMID33794697
PMCPMC8239992
OpenAlexW3148294016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.