Evidence map›Paper›PMID 33794646›Full record

ArticleCirculation. Genomic and precision medicine2021

Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.

David Rhainds, Chris J Packard, Mathieu R Brodeur, Eric J Niesor, Frank M Sacks, J Wouter Jukema, R Scott Wright, David D Waters, Therese Heinonen, Donald M Black and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 5 countries.

David RhaindsMontreal Heart Institute (D.R., M.R.B., M.-P.D., J.-C.T.).
Chris J PackardUniversity of Glasgow, United Kingdom (C.J.P.).
Mathieu R BrodeurMontreal Heart Institute (D.R., M.R.B., M.-P.D., J.-C.T.).
Eric J NiesorHartis Pharma, Nyon, Switzerland (E.J.N.).
Frank M SacksHarvard School of Public Health, Boston, MA (F.M.S.).
J Wouter JukemaLeiden University, the Netherlands (J.W.J.).
R Scott WrightMayo Clinic, Rochester, MN (R.S.W.).
David D WatersSchool of Medicine, University of California, San Francisco (D.D.W.).
Therese HeinonenDalCor Pharmaceuticals, Leatherhead, United Kingdom & Zug, Switzerland (T.H., D.M.B., F.L.-T.).
Donald M BlackDalCor Pharmaceuticals, Leatherhead, United Kingdom & Zug, Switzerland (T.H., D.M.B., F.L.-T.).
Fouzia Laghrissi-ThodeDalCor Pharmaceuticals, Leatherhead, United Kingdom & Zug, Switzerland (T.H., D.M.B., F.L.-T.).
Marie-Pierre DubéMontreal Heart Institute (D.R., M.R.B., M.-P.D., J.-C.T.).
Marc A PfefferBrigham and Women's Hospital & Harvard Medical School, Boston, MA (M.A.P.).
Jean-Claude TardifMontreal Heart Institute (D.R., M.R.B., M.-P.D., J.-C.T.).
Montreal Heart Institute · CATwitter (United States) · USBrigham and Women's Hospital · USEuropean Respiratory Society · CHHewlett-Packard (United Kingdom) · GBLeiden University · NLMassachusetts Department of Public Health · USMayo Clinic · USUniversity of California, San Francisco · USWeatherford (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (

Indexed as

Precision MedicineAdenylyl CyclasesAmidesBiomarkersCardiovascular DiseasesCholesterolCholesterol Ester Transfer ProteinsEstersGenotypeHumansPharmacogeneticsSulfhydryl Compoundsadenylate cyclase 9Adenylyl CyclasesAmidesBiomarkersCholesterolCholesterol Ester Transfer ProteinsdalcetrapibEstersSulfhydryl Compoundsacute coronary syndromeadenylate cyclasedalcetrapibmacrophagesprecision medicine

Identifiers

PMID33794646
PMCPMC8284386
OpenAlexW3146142701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.